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The head mesodermal cell couples FMRFamide neuropeptide signaling with rhythmic muscle contraction in C. elegans

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  • Ukjin Choi

    (University of Southern California
    University of Southern California)

  • Mingxi Hu

    (University of Southern California)

  • Qixin Zhang

    (University of Southern California)

  • Derek Sieburth

    (University of Southern California
    University of Southern California)

Abstract

FMRFamides are evolutionarily conserved neuropeptides that play critical roles in behavior, energy balance, and reproduction. Here, we show that FMRFamide signaling from the nervous system is critical for the rhythmic activation of a single cell of previously unknown function, the head mesodermal cell (hmc) in C. elegans. Behavioral, calcium imaging, and genetic studies reveal that release of the FLP-22 neuropeptide from the AVL neuron in response to pacemaker signaling activates hmc every 50 s through an frpr-17 G protein-coupled receptor (GPCR) and a protein kinase A signaling cascade in hmc. hmc activation results in muscle contraction through coupling by gap junctions composed of UNC-9/Innexin. hmc activation is inhibited by the neuronal release of a second FMRFamide-like neuropeptide, FLP-9, which functions through its GPCR, frpr-21, in hmc. This study reveals a function for two opposing FMRFamide signaling pathways in controlling the rhythmic activation of a target cell through volume transmission.

Suggested Citation

  • Ukjin Choi & Mingxi Hu & Qixin Zhang & Derek Sieburth, 2023. "The head mesodermal cell couples FMRFamide neuropeptide signaling with rhythmic muscle contraction in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39955-8
    DOI: 10.1038/s41467-023-39955-8
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    1. Jingyuan Jiang & Yifan Su & Ruilin Zhang & Haiwen Li & Louis Tao & Qiang Liu, 2022. "C. elegans enteric motor neurons fire synchronized action potentials underlying the defecation motor program," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
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