IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-39934-z.html
   My bibliography  Save this article

Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease

Author

Listed:
  • Mariya M. Kucherenko

    (Deutsches Herzzentrum der Charité (DHZC)
    corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany
    Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    DZHK (German Centre for Cardiovascular Research))

  • Pengchao Sang

    (Deutsches Herzzentrum der Charité (DHZC)
    corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany
    Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    DZHK (German Centre for Cardiovascular Research))

  • Juquan Yao

    (Deutsches Herzzentrum der Charité (DHZC)
    corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany
    Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Tara Gransar

    (Deutsches Herzzentrum der Charité (DHZC)
    corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany
    Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin)

  • Saphala Dhital

    (Clemson University)

  • Jana Grune

    (Deutsches Herzzentrum der Charité (DHZC)
    corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany
    Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    DZHK (German Centre for Cardiovascular Research))

  • Szandor Simmons

    (Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    DZHK (German Centre for Cardiovascular Research))

  • Laura Michalick

    (Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    DZHK (German Centre for Cardiovascular Research))

  • Dag Wulsten

    (Berlin Institute of Health at Charité - Universitätsmedizin Berlin)

  • Mario Thiele

    (Berlin Institute of Health at Charité - Universitätsmedizin Berlin)

  • Orr Shomroni

    (NGS Integrative Genomics (NIG))

  • Felix Hennig

    (Deutsches Herzzentrum der Charité (DHZC)
    corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany
    DZHK (German Centre for Cardiovascular Research))

  • Ruhi Yeter

    (Deutsches Herzzentrum der Charité (DHZC)
    corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany)

  • Natalia Solowjowa

    (Deutsches Herzzentrum der Charité (DHZC)
    corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany
    DZHK (German Centre for Cardiovascular Research))

  • Gabriela Salinas

    (NGS Integrative Genomics (NIG))

  • Georg N. Duda

    (Berlin Institute of Health at Charité - Universitätsmedizin Berlin
    Berlin Institute of Health at Charité - Universitätsmedizin Berlin)

  • Volkmar Falk

    (Deutsches Herzzentrum der Charité (DHZC)
    corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany
    DZHK (German Centre for Cardiovascular Research)
    Translational Cardiovascular Technology, LFW C 13.2, ETH Zurich)

  • Naren R. Vyavahare

    (Clemson University)

  • Wolfgang M. Kuebler

    (Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
    DZHK (German Centre for Cardiovascular Research)
    University of Toronto)

  • Christoph Knosalla

    (Deutsches Herzzentrum der Charité (DHZC)
    corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany
    DZHK (German Centre for Cardiovascular Research))

Abstract

Pulmonary hypertension worsens outcome in left heart disease. Stiffening of the pulmonary artery may drive this pathology by increasing right ventricular dysfunction and lung vascular remodeling. Here we show increased stiffness of pulmonary arteries from patients with left heart disease that correlates with impaired pulmonary hemodynamics. Extracellular matrix remodeling in the pulmonary arterial wall, manifested by dysregulated genes implicated in elastin degradation, precedes the onset of pulmonary hypertension. The resulting degradation of elastic fibers is paralleled by an accumulation of fibrillar collagens. Pentagalloyl glucose preserves arterial elastic fibers from elastolysis, reduces inflammation and collagen accumulation, improves pulmonary artery biomechanics, and normalizes right ventricular and pulmonary hemodynamics in a rat model of pulmonary hypertension due to left heart disease. Thus, targeting extracellular matrix remodeling may present a therapeutic approach for pulmonary hypertension due to left heart disease.

Suggested Citation

  • Mariya M. Kucherenko & Pengchao Sang & Juquan Yao & Tara Gransar & Saphala Dhital & Jana Grune & Szandor Simmons & Laura Michalick & Dag Wulsten & Mario Thiele & Orr Shomroni & Felix Hennig & Ruhi Yet, 2023. "Elastin stabilization prevents impaired biomechanics in human pulmonary arteries and pulmonary hypertension in rats with left heart disease," Nature Communications, Nature, vol. 14(1), pages 1-23, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39934-z
    DOI: 10.1038/s41467-023-39934-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-39934-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-39934-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Mariya M. Kucherenko & Halyna R. Shcherbata, 2018. "Stress-dependent miR-980 regulation of Rbfox1/A2bp1 promotes ribonucleoprotein granule formation and cell survival," Nature Communications, Nature, vol. 9(1), pages 1-20, December.
    2. A. Petersen & A. Princ & G. Korus & A. Ellinghaus & H. Leemhuis & A. Herrera & A. Klaumünzer & S. Schreivogel & A. Woloszyk & K. Schmidt-Bleek & S. Geissler & I. Heschel & G. N. Duda, 2018. "A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yu Chang & Chuandong Xie & Hong Liu & Shengli Huang & Pengfei Wang & Wenling Qin & Hailong Yan, 2022. "Organocatalytic atroposelective construction of axially chiral N, N- and N, S-1,2-azoles through novel ring formation approach," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. M. Gabriele Bixel & Kishor K. Sivaraj & Melanie Timmen & Vishal Mohanakrishnan & Anusha Aravamudhan & Susanne Adams & Bong-Ihn Koh & Hyun-Woo Jeong & Kai Kruse & Richard Stange & Ralf H. Adams, 2024. "Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    3. Wenwen Liu & Han Zhao & Chenguang Zhang & Shiqi Xu & Fengyi Zhang & Ling Wei & Fangyu Zhu & Ying Chen & Yumin Chen & Ying Huang & Mingming Xu & Ying He & Boon Chin Heng & Jinxing Zhang & Yang Shen & X, 2023. "In situ activation of flexible magnetoelectric membrane enhances bone defect repair," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39934-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.