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Symbiont-host interactome mapping reveals effector-targeted modulation of hormone networks and activation of growth promotion

Author

Listed:
  • Rory Osborne

    (University of Warwick
    University of Birmingham)

  • Laura Rehneke

    (Justus Liebig University)

  • Silke Lehmann

    (University of Warwick
    Southern Brittany University)

  • Jemma Roberts

    (University of Warwick)

  • Melina Altmann

    (Helmholtz Munich)

  • Stefan Altmann

    (Helmholtz Munich)

  • Yingqi Zhang

    (Northwest A&F University)

  • Eva Köpff

    (Ulm University)

  • Ana Dominguez-Ferreras

    (University of Warwick)

  • Emeka Okechukwu

    (University of Warwick)

  • Chrysi Sergaki

    (University of Warwick)

  • Charlotte Rich-Griffin

    (University of Warwick)

  • Vardis Ntoukakis

    (University of Warwick)

  • Ruth Eichmann

    (Justus Liebig University)

  • Weixing Shan

    (Northwest A&F University)

  • Pascal Falter-Braun

    (Helmholtz Munich
    Ludwig-Maximilians-University München)

  • Patrick Schäfer

    (Justus Liebig University)

Abstract

Plants have benefited from interactions with symbionts for coping with challenging environments since the colonisation of land. The mechanisms of symbiont-mediated beneficial effects and similarities and differences to pathogen strategies are mostly unknown. Here, we use 106 (effector-) proteins, secreted by the symbiont Serendipita indica (Si) to modulate host physiology, to map interactions with Arabidopsis thaliana host proteins. Using integrative network analysis, we show significant convergence on target-proteins shared with pathogens and exclusive targeting of Arabidopsis proteins in the phytohormone signalling network. Functional in planta screening and phenotyping of Si effectors and interacting proteins reveals previously unknown hormone functions of Arabidopsis proteins and direct beneficial activities mediated by effectors in Arabidopsis. Thus, symbionts and pathogens target a shared molecular microbe-host interface. At the same time Si effectors specifically target the plant hormone network and constitute a powerful resource for elucidating the signalling network function and boosting plant productivity.

Suggested Citation

  • Rory Osborne & Laura Rehneke & Silke Lehmann & Jemma Roberts & Melina Altmann & Stefan Altmann & Yingqi Zhang & Eva Köpff & Ana Dominguez-Ferreras & Emeka Okechukwu & Chrysi Sergaki & Charlotte Rich-G, 2023. "Symbiont-host interactome mapping reveals effector-targeted modulation of hormone networks and activation of growth promotion," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39885-5
    DOI: 10.1038/s41467-023-39885-5
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    References listed on IDEAS

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    1. Paul Kenrick & Peter R. Crane, 1997. "The origin and early evolution of plants on land," Nature, Nature, vol. 389(6646), pages 33-39, September.
    2. Melina Altmann & Stefan Altmann & Patricia A. Rodriguez & Benjamin Weller & Lena Elorduy Vergara & Julius Palme & Nora Marín-de la Rosa & Mayra Sauer & Marion Wenig & José Antonio Villaécija-Aguilar &, 2020. "Extensive signal integration by the phytohormone protein network," Nature, Nature, vol. 583(7815), pages 271-276, July.
    3. Melina Altmann & Stefan Altmann & Patricia A. Rodriguez & Benjamin Weller & Lena Elorduy Vergara & Julius Palme & Nora Marín-de Rosa & Mayra Sauer & Marion Wenig & José Antonio Villaécija-Aguilar & Je, 2020. "Publisher Correction: Extensive signal integration by the phytohormone protein network," Nature, Nature, vol. 584(7821), pages 34-34, August.
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