IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-39786-7.html
   My bibliography  Save this article

Challenges in developing Geroscience trials

Author

Listed:
  • Yves Rolland

    (Gérontopôle de Toulouse, IHU HealthAge, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse
    CERPOP UMR 1295, University of Toulouse III, Inserm, UPS)

  • Felipe Sierra

    (Hevolution Foundation)

  • Luigi Ferrucci

    (National Institutes of Health)

  • Nir Barzilai

    (Albert Einstein College of Medicine)

  • Rafael Cabo

    (National Institutes of Health)

  • Joan Mannick

    (Life Biosciences)

  • Anthony Oliva

    (Longeveron Inc.)

  • William Evans

    (University of California)

  • Davide Angioni

    (Gérontopôle de Toulouse, IHU HealthAge, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse)

  • Philipe Souto Barreto

    (Gérontopôle de Toulouse, IHU HealthAge, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse
    CERPOP UMR 1295, University of Toulouse III, Inserm, UPS)

  • Jeremy Raffin

    (Gérontopôle de Toulouse, IHU HealthAge, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse
    CERPOP UMR 1295, University of Toulouse III, Inserm, UPS)

  • Bruno Vellas

    (Gérontopôle de Toulouse, IHU HealthAge, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse
    CERPOP UMR 1295, University of Toulouse III, Inserm, UPS)

  • James L. Kirkland

    (American Federation for Aging Research)

Abstract

Geroscience is becoming a major hope for preventing age-related diseases and loss of function by targeting biological mechanisms of aging. This unprecedented paradigm shift requires optimizing the design of future clinical studies related to aging in humans. Researchers will face a number of challenges, including ideal populations to study, which lifestyle and Gerotherapeutic interventions to test initially, selecting key primary and secondary outcomes of such clinical trials, and which age-related biomarkers are most valuable for both selecting interventions and predicting or monitoring clinical responses (“Gerodiagnostics”). This article reports the main results of a Task Force of experts in Geroscience.

Suggested Citation

  • Yves Rolland & Felipe Sierra & Luigi Ferrucci & Nir Barzilai & Rafael Cabo & Joan Mannick & Anthony Oliva & William Evans & Davide Angioni & Philipe Souto Barreto & Jeremy Raffin & Bruno Vellas & Jame, 2023. "Challenges in developing Geroscience trials," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39786-7
    DOI: 10.1038/s41467-023-39786-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-39786-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-39786-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Xu Zhang & Vesselina M. Pearsall & Chase M. Carver & Elizabeth J. Atkinson & Benjamin D. S. Clarkson & Ethan M. Grund & Michelle Baez-Faria & Kevin D. Pavelko & Jennifer M. Kachergus & Thomas A. White, 2022. "Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39786-7. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.