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Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent

Author

Listed:
  • Nicholas D. Calvert

    (University of Ottawa)

  • Alexia Kirby

    (University of Ottawa)

  • Mojmír Suchý

    (University of Ottawa)

  • Peter Pallister

    (Carleton University)

  • Aidan A. Torrens

    (University of Ottawa)

  • Dylan Burger

    (University of Ottawa)

  • Gerd Melkus

    (The Ottawa Hospital
    University of Ottawa)

  • Nicola Schieda

    (University of Ottawa)

  • Adam J. Shuhendler

    (University of Ottawa
    University of Ottawa
    University of Ottawa Heart Institute)

Abstract

Chronic kidney disease (CKD) and acute kidney injury (AKI) are ongoing global health burdens. Glomerular filtration rate (GFR) is the gold standard measure of kidney function, with clinical estimates providing a global assessment of kidney health without spatial information of kidney- or region-specific dysfunction. The addition of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to the anatomical imaging already performed would yield a ‘one-stop-shop’ for renal assessment in cases of suspected AKI and CKD. Towards urography by DCE-MRI, we evaluated a class of nitrogen-centered organic radicals known as verdazyls, which are extremely stable even in highly reducing environments. A glucose-modified verdazyl, glucoverdazyl, provided contrast limited to kidney and bladder, affording functional kidney evaluation in mouse models of unilateral ureteral obstruction (UUO) and folic acid-induced nephropathy (FAN). Imaging outcomes correlated with histology and hematology assessing kidney dysfunction, and glucoverdazyl clearance rates were found to be a reliable surrogate measure of GFR.

Suggested Citation

  • Nicholas D. Calvert & Alexia Kirby & Mojmír Suchý & Peter Pallister & Aidan A. Torrens & Dylan Burger & Gerd Melkus & Nicola Schieda & Adam J. Shuhendler, 2023. "Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39720-x
    DOI: 10.1038/s41467-023-39720-x
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