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Inhibition of chitin deacetylases to attenuate plant fungal diseases

Author

Listed:
  • Lin Liu

    (Dalian University of Technology
    Chinese Academy of Agricultural Sciences
    Chinese Academy of Agricultural Sciences)

  • Yeqiang Xia

    (Nanjing Agricultural University
    Nanjing Agricultural University
    Nanjing Agricultural University)

  • Yingchen Li

    (Chinese Academy of Agricultural Sciences)

  • Yong Zhou

    (Dalian University of Technology)

  • Xiaofeng Su

    (Chinese Academy of Agricultural Sciences)

  • Xiaojing Yan

    (Chinese Academy of Agricultural Sciences)

  • Yan Wang

    (Nanjing Agricultural University
    Nanjing Agricultural University
    Nanjing Agricultural University)

  • Wende Liu

    (Chinese Academy of Agricultural Sciences)

  • Hongmei Cheng

    (Chinese Academy of Agricultural Sciences)

  • Yuanchao Wang

    (Nanjing Agricultural University
    Nanjing Agricultural University
    Nanjing Agricultural University)

  • Qing Yang

    (Dalian University of Technology
    Chinese Academy of Agricultural Sciences
    Chinese Academy of Agricultural Sciences)

Abstract

Phytopathogenic fungi secrete chitin deacetylase (CDA) to escape the host’s immunological defense during infection. Here, we showed that the deacetylation activity of CDA toward chitin is essential for fungal virulence. Five crystal structures of two representative and phylogenetically distant phytopathogenic fungal CDAs, VdPDA1 from Verticillium dahliae and Pst_13661 from Puccinia striiformis f. sp. tritici, were obtained in ligand-free and inhibitor-bound forms. These structures suggested that both CDAs have an identical substrate-binding pocket and an Asp-His-His triad for coordinating a transition metal ion. Based on the structural identities, four compounds with a benzohydroxamic acid (BHA) moiety were obtained as phytopathogenic fungal CDA inhibitors. BHA exhibited high effectiveness in attenuating fungal diseases in wheat, soybean, and cotton. Our findings revealed that phytopathogenic fungal CDAs share common structural features, and provided BHA as a lead compound for the design of CDA inhibitors aimed at attenuating crop fungal diseases.

Suggested Citation

  • Lin Liu & Yeqiang Xia & Yingchen Li & Yong Zhou & Xiaofeng Su & Xiaojing Yan & Yan Wang & Wende Liu & Hongmei Cheng & Yuanchao Wang & Qing Yang, 2023. "Inhibition of chitin deacetylases to attenuate plant fungal diseases," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39562-7
    DOI: 10.1038/s41467-023-39562-7
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