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The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma

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Listed:
  • Meng Zhou

    (Wenzhou Medical University)

  • Siqi Bao

    (Wenzhou Medical University)

  • Tongyang Gong

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Qiang Wang

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Jie Sun

    (Wenzhou Medical University)

  • Jiaqi Li

    (Wenzhou Medical University)

  • Minyi Lu

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Wanyuan Sun

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Jianzhong Su

    (Wenzhou Medical University)

  • Hongyan Chen

    (Chinese Academy of Medical Sciences and Peking Union Medical College
    Chinese Academy of Medical Sciences and Peking Union Medical College)

  • Zhihua Liu

    (Chinese Academy of Medical Sciences and Peking Union Medical College)

Abstract

Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically relevant biomarkers for early detection. Here, we comprehensively characterized the transcriptional landscape of long non-coding RNAs (lncRNAs) in paired tumor and normal tissue specimens from 93 ESCC patients, and identified six key malignancy-specific lncRNAs that were integrated into a Multi-LncRNA Malignancy Risk Probability model (MLMRPscore). The MLMRPscore performed robustly in distinguishing ESCC from normal controls in multiple in-house and external multicenter validation cohorts, including early-stage I/II cancer. In addition, five candidate lncRNAs were confirmed to have non-invasive diagnostic potential in our institute plasma cohort, showing superior or comparable diagnostic accuracy to current clinical serological markers. Overall, this study highlights the profound and robust dysregulation of lncRNAs in ESCC and demonstrates the potential of lncRNAs as non-invasive biomarkers for the early detection of ESCC.

Suggested Citation

  • Meng Zhou & Siqi Bao & Tongyang Gong & Qiang Wang & Jie Sun & Jiaqi Li & Minyi Lu & Wanyuan Sun & Jianzhong Su & Hongyan Chen & Zhihua Liu, 2023. "The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39530-1
    DOI: 10.1038/s41467-023-39530-1
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