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Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics

Author

Listed:
  • Hiroaki Kikuchi

    (National Institutes of Health)

  • Chung-Lin Chou

    (National Institutes of Health)

  • Chin-Rang Yang

    (National Institutes of Health)

  • Lihe Chen

    (National Institutes of Health)

  • Hyun Jun Jung

    (Johns Hopkins University School of Medicine)

  • Euijung Park

    (National Institutes of Health)

  • Kavee Limbutara

    (Chulalongkorn University)

  • Benjamin Carter

    (Lung and Blood Institute, NIH)

  • Zhi-Hong Yang

    (National Institutes of Health)

  • Julia F. Kun

    (National Institutes of Health)

  • Alan T. Remaley

    (National Institutes of Health)

  • Mark A. Knepper

    (National Institutes of Health)

Abstract

Loss of a kidney results in compensatory growth of the remaining kidney, a phenomenon of considerable clinical importance. However, the mechanisms involved are largely unknown. Here, we use a multi-omic approach in a unilateral nephrectomy model in male mice to identify signaling processes associated with renal compensatory hypertrophy, demonstrating that the lipid-activated transcription factor peroxisome proliferator-activated receptor alpha (PPARα) is an important determinant of proximal tubule cell size and is a likely mediator of compensatory proximal tubule hypertrophy.

Suggested Citation

  • Hiroaki Kikuchi & Chung-Lin Chou & Chin-Rang Yang & Lihe Chen & Hyun Jun Jung & Euijung Park & Kavee Limbutara & Benjamin Carter & Zhi-Hong Yang & Julia F. Kun & Alan T. Remaley & Mark A. Knepper, 2023. "Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38958-9
    DOI: 10.1038/s41467-023-38958-9
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