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Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank

Author

Listed:
  • Oana A. Zeleznik

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Jae H. Kang

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • Jessica Lasky-Su

    (Brigham and Women’s Hospital
    Harvard Medical School)

  • A. Heather Eliassen

    (Brigham and Women’s Hospital
    Harvard Medical School
    Harvard T.H. Chan School of Public Health
    Harvard T.H. Chan School of Public Health)

  • Lisa Frueh

    (Brigham and Women’s Hospital)

  • Clary B. Clish

    (Broad Institute of Massachusetts Institute of Technology and Harvard)

  • Bernard A. Rosner

    (Brigham and Women’s Hospital
    Harvard Medical School
    Harvard T.H. Chan School of Public Health)

  • Tobias Elze

    (Harvard Medical School
    Schepens Research Eye Institute of Massachusetts Eye and Ear)

  • Pirro Hysi

    (King’s College London
    King’s College London
    St. Thomas’ Hospital)

  • Anthony Khawaja

    (Moorfields Eye Hospital
    University College London)

  • Janey L. Wiggs

    (Harvard Medical School
    Massachusetts Eye and Ear)

  • Louis R. Pasquale

    (Icahn School of Medicine at Mount Sinai)

Abstract

Glaucoma is a progressive optic neuropathy and a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma is the most common form, and yet the etiology of this multifactorial disease is poorly understood. We aimed to identify plasma metabolites associated with the risk of developing POAG in a case-control study (599 cases and 599 matched controls) nested within the Nurses’ Health Studies, and Health Professionals’ Follow-Up Study. Plasma metabolites were measured with LC-MS/MS at the Broad Institute (Cambridge, MA, USA); 369 metabolites from 18 metabolite classes passed quality control analyses. For comparison, in a cross-sectional study in the UK Biobank, 168 metabolites were measured in plasma samples from 2,238 prevalent glaucoma cases and 44,723 controls using NMR spectroscopy (Nightingale, Finland; version 2020). Here we show higher levels of diglycerides and triglycerides are adversely associated with glaucoma in all four cohorts, suggesting that they play an important role in glaucoma pathogenesis.

Suggested Citation

  • Oana A. Zeleznik & Jae H. Kang & Jessica Lasky-Su & A. Heather Eliassen & Lisa Frueh & Clary B. Clish & Bernard A. Rosner & Tobias Elze & Pirro Hysi & Anthony Khawaja & Janey L. Wiggs & Louis R. Pasqu, 2023. "Plasma metabolite profile for primary open-angle glaucoma in three US cohorts and the UK Biobank," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38466-w
    DOI: 10.1038/s41467-023-38466-w
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    References listed on IDEAS

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    1. Kevin Huynh & Wei Ling Florence Lim & Corey Giles & Kaushala S. Jayawardana & Agus Salim & Natalie A. Mellett & Adam Alexander T. Smith & Gavriel Olshansky & Brian G. Drew & Pratishtha Chatterjee & Ia, 2020. "Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    2. Cédric Benoist d’Azy & Bruno Pereira & Frédéric Chiambaretta & Frédéric Dutheil, 2016. "Oxidative and Anti-Oxidative Stress Markers in Chronic Glaucoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-20, December.
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