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A visual opsin from jellyfish enables precise temporal control of G protein signalling

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  • Michiel Wyk

    (University of Bern
    University of Bern)

  • Sonja Kleinlogel

    (University of Bern
    University of Bern
    Roche Pharma and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, F. Hoffmann-La Roche Ltd)

Abstract

Phototransduction is mediated by distinct types of G protein cascades in different animal taxa: bilateral invertebrates typically utilise the Gαq pathway whereas vertebrates typically utilise the Gαt(i/o) pathway. By contrast, photoreceptors in jellyfish (Cnidaria) utilise the Gαs intracellular pathway, similar to olfactory transduction in mammals1. How this habitually slow pathway has adapted to support dynamic vision in jellyfish remains unknown. Here we study a light-sensing protein (rhodopsin) from the box jellyfish Carybdea rastonii and uncover a mechanism that dramatically speeds up phototransduction: an uninterrupted G protein-coupled receptor – G protein complex. Unlike known G protein-coupled receptors (GPCRs), this rhodopsin constitutively binds a single downstream Gαs partner to enable G-protein activation and inactivation within tens of milliseconds. We use this GPCR in a viral gene therapy to restore light responses in blind mice.

Suggested Citation

  • Michiel Wyk & Sonja Kleinlogel, 2023. "A visual opsin from jellyfish enables precise temporal control of G protein signalling," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38231-z
    DOI: 10.1038/s41467-023-38231-z
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    References listed on IDEAS

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    1. Michael H. Berry & Amy Holt & Autoosa Salari & Julia Veit & Meike Visel & Joshua Levitz & Krisha Aghi & Benjamin M. Gaub & Benjamin Sivyer & John G. Flannery & Ehud Y. Isacoff, 2019. "Restoration of high-sensitivity and adapting vision with a cone opsin," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
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