IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-38088-2.html
   My bibliography  Save this article

Pancreatic cancer is associated with medication changes prior to clinical diagnosis

Author

Listed:
  • Yin Zhang

    (Dana-Farber Cancer Institute and Harvard Medical School
    Harvard T. H. Chan School of Public Health)

  • Qiao-Li Wang

    (Dana-Farber Cancer Institute and Harvard Medical School
    Karolinka Institutet)

  • Chen Yuan

    (Dana-Farber Cancer Institute and Harvard Medical School)

  • Alice A. Lee

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Ana Babic

    (Dana-Farber Cancer Institute and Harvard Medical School)

  • Kimmie Ng

    (Dana-Farber Cancer Institute and Harvard Medical School)

  • Kimberly Perez

    (Dana-Farber Cancer Institute and Harvard Medical School)

  • Jonathan A. Nowak

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Jesper Lagergren

    (Karolinska University Hospital
    King’s College London)

  • Meir J. Stampfer

    (Harvard T. H. Chan School of Public Health
    Brigham and Women’s Hospital and Harvard Medical School
    Harvard T. H. Chan School of Public Health)

  • Edward L. Giovannucci

    (Harvard T. H. Chan School of Public Health
    Harvard T. H. Chan School of Public Health)

  • Chris Sander

    (Dana-Farber Cancer Institute
    Harvard Medical School
    Broad Institute of Harvard and MIT)

  • Michael H. Rosenthal

    (Brigham and Women’s Hospital and Harvard Medical School)

  • Peter Kraft

    (Harvard T. H. Chan School of Public Health
    Harvard T.H. Chan School of Public Health)

  • Brian M. Wolpin

    (Dana-Farber Cancer Institute and Harvard Medical School)

Abstract

Patients with pancreatic ductal adenocarcinoma (PDAC) commonly develop symptoms and signs in the 1–2 years before diagnosis that can result in changes to medications. We investigate recent medication changes and PDAC diagnosis in Nurses’ Health Study (NHS; females) and Health Professionals Follow-up Study (HPFS; males), including up to 148,973 U.S. participants followed for 2,994,057 person-years and 991 incident PDAC cases. Here we show recent initiation of antidiabetic (NHS) or anticoagulant (NHS, HFS) medications and cessation of antihypertensive medications (NHS, HPFS) are associated with pancreatic cancer diagnosis in the next 2 years. Two-year PDAC risk increases as number of relevant medication changes increases (P-trend

Suggested Citation

  • Yin Zhang & Qiao-Li Wang & Chen Yuan & Alice A. Lee & Ana Babic & Kimmie Ng & Kimberly Perez & Jonathan A. Nowak & Jesper Lagergren & Meir J. Stampfer & Edward L. Giovannucci & Chris Sander & Michael , 2023. "Pancreatic cancer is associated with medication changes prior to clinical diagnosis," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38088-2
    DOI: 10.1038/s41467-023-38088-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-38088-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-38088-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Laura V. Danai & Ana Babic & Michael H. Rosenthal & Emily A. Dennstedt & Alexander Muir & Evan C. Lien & Jared R. Mayers & Karen Tai & Allison N. Lau & Paul Jones-Sali & Carla M. Prado & Gloria M. Pet, 2018. "Altered exocrine function can drive adipose wasting in early pancreatic cancer," Nature, Nature, vol. 558(7711), pages 600-604, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ana Babic & Michael H. Rosenthal & Tilak K. Sundaresan & Natalia Khalaf & Valerie Lee & Lauren K. Brais & Maureen Loftus & Leah Caplan & Sarah Denning & Anamol Gurung & Joanna Harrod & Khoschy Schawka, 2023. "Adipose tissue and skeletal muscle wasting precede clinical diagnosis of pancreatic cancer," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    2. Ali Vaziri-Gohar & Jonathan J. Hue & Ata Abbas & Hallie J. Graor & Omid Hajihassani & Mehrdad Zarei & George Titomihelakis & John Feczko & Moeez Rathore & Sylwia Chelstowska & Alexander W. Loftus & Ru, 2023. "Increased glucose availability sensitizes pancreatic cancer to chemotherapy," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38088-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.