IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-37983-y.html
   My bibliography  Save this article

A DBHS family member regulates male determination in the filariasis vector Armigeres subalbatus

Author

Listed:
  • Peiwen Liu

    (Southern Medical University)

  • Wenqiang Yang

    (Southern Medical University)

  • Ling Kong

    (Southern Medical University)

  • Siyu Zhao

    (Southern Medical University)

  • Zhensheng Xie

    (Southern Medical University)

  • Yijie Zhao

    (Southern Medical University)

  • Yang Wu

    (Southern Medical University)

  • Yijia Guo

    (Southern Medical University)

  • Yugu Xie

    (Southern Medical University)

  • Tong Liu

    (Southern Medical University)

  • Binbin Jin

    (Southern Medical University)

  • Jinbao Gu

    (Southern Medical University)

  • Zhijian Jake Tu

    (Virginia Tech)

  • Anthony A. James

    (University of California)

  • Xiao-Guang Chen

    (Southern Medical University)

Abstract

The initial signals governing sex determination vary widely among insects. Here we show that Armigeres subalbatus M factor (AsuMf), a male-specific duplication of an autosomal gene of the Drosophila behaviour/human splicing (DBHS) gene family, is the potential primary signal for sex determination in the human filariasis vector mosquito, Ar. subalbatus. Our results show that AsuMf satisfies two fundamental requirements of an M factor: male-specific expression and early embryonic expression. Ablations of AsuMf result in a shift from male- to female-specific splicing of doublesex and fruitless, leading to feminization of males both in morphology and general transcription profile. These data support the conclusion that AsuMf is essential for male development in Ar. subalbatus and reveal a male-determining factor that is derived from duplication and subsequent neofunctionalization of a member of the conserved DBHS family.

Suggested Citation

  • Peiwen Liu & Wenqiang Yang & Ling Kong & Siyu Zhao & Zhensheng Xie & Yijie Zhao & Yang Wu & Yijia Guo & Yugu Xie & Tong Liu & Binbin Jin & Jinbao Gu & Zhijian Jake Tu & Anthony A. James & Xiao-Guang C, 2023. "A DBHS family member regulates male determination in the filariasis vector Armigeres subalbatus," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37983-y
    DOI: 10.1038/s41467-023-37983-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-37983-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-37983-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37983-y. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.