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ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis

Author

Listed:
  • Mariana I. Giassetti

    (Washington State University
    Washington State University)

  • Deqiang Miao

    (Washington State University
    Washington State University)

  • Nathan C. Law

    (Washington State University
    Washington State University)

  • Melissa J. Oatley

    (Washington State University
    Washington State University)

  • Julie Park

    (Washington State University
    Washington State University)

  • LeeLa D. Robinson

    (Washington State University
    Washington State University)

  • Lisette A. Maddison

    (Washington State University)

  • Miranda L. Bernhardt

    (Washington State University)

  • Jon M. Oatley

    (Washington State University
    Washington State University)

Abstract

In sexual reproduction, sperm contribute half the genomic material required for creation of offspring yet core molecular mechanisms essential for their formation are undefined. Here, the α-arrestin molecule arrestin-domain containing 5 (ARRDC5) is identified as an essential regulator of mammalian spermatogenesis. Multispecies testicular tissue transcriptome profiling indicates that expression of Arrdc5 is testis enriched, if not specific, in mice, pigs, cattle, and humans. Knockout of Arrdc5 in mice leads to male specific sterility due to production of low numbers of sperm that are immotile and malformed. Spermiogenesis, the final phase of spermatogenesis when round spermatids transform to spermatozoa, is defective in testes of Arrdc5 deficient mice. Also, epididymal sperm in Arrdc5 knockouts are unable to capacitate and fertilize oocytes. These findings establish ARRDC5 as an essential regulator of mammalian spermatogenesis. Considering the role of arrestin molecules as modulators of cellular signaling and ubiquitination, ARRDC5 is a potential male contraceptive target.

Suggested Citation

  • Mariana I. Giassetti & Deqiang Miao & Nathan C. Law & Melissa J. Oatley & Julie Park & LeeLa D. Robinson & Lisette A. Maddison & Miranda L. Bernhardt & Jon M. Oatley, 2023. "ARRDC5 expression is conserved in mammalian testes and required for normal sperm morphogenesis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37735-y
    DOI: 10.1038/s41467-023-37735-y
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    References listed on IDEAS

    as
    1. Nathan C. Law & Melissa J. Oatley & Jon M. Oatley, 2019. "Developmental kinetics and transcriptome dynamics of stem cell specification in the spermatogenic lineage," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    2. JongDae Shin & Michael Bossenz & Young Chung & Hong Ma & Meg Byron & Naoko Taniguchi-Ishigaki & Xiaochun Zhu & Baowei Jiao & Lisa L. Hall & Michael R. Green & Stephen N. Jones & Irm Hermans-Borgmeyer , 2010. "Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice," Nature, Nature, vol. 467(7318), pages 977-981, October.
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