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Screw sense excess and reversals of helical polymers in solution

Author

Listed:
  • Francisco Rey-Tarrío

    (University of Santiago de Compostela
    University of Santiago de Compostela)

  • Rafael Rodríguez

    (University of Santiago de Compostela
    University of Santiago de Compostela)

  • Emilio Quiñoá

    (University of Santiago de Compostela
    University of Santiago de Compostela)

  • Félix Freire

    (University of Santiago de Compostela
    University of Santiago de Compostela)

Abstract

The helix reversal is a structural motif found in helical polymers in the solid state, but whose existence is elusive in solution. Herein, we have shown how the photochemical electrocyclization (PEC) of poly(phenylacetylene)s (PPAs) can be used to determine not only the presence of helix reversals in polymer solution, but also to estimate the screw sense excess. To perform these studies, we used a library of well folded PPAs and different copolymers series made by enantiomeric comonomers that show chiral conflict effect. The results obtained indicate that the PEC of a PPA will depend on the helical scaffold adopted by the PPA backbone and on its folding degree. Then, from these studies it is possible to determine the screw sense excess of a PPA, highly important in applications such as chiral stationary phases in HPLC or asymmetric synthesis.

Suggested Citation

  • Francisco Rey-Tarrío & Rafael Rodríguez & Emilio Quiñoá & Félix Freire, 2023. "Screw sense excess and reversals of helical polymers in solution," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37405-z
    DOI: 10.1038/s41467-023-37405-z
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