IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-37399-8.html
   My bibliography  Save this article

Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry

Author

Listed:
  • Kanako Watanabe

    (Niigata University Graduate School of Health Sciences)

  • Tomoichiro Oka

    (National Institute of Infectious Diseases)

  • Hirotaka Takagi

    (National Institute of Infectious Diseases)

  • Sergei Anisimov

    (Niigata University Graduate School of Medical and Dental Sciences)

  • Shun-ichi Yamashita

    (Niigata University Graduate School of Medical and Dental Sciences)

  • Yoshinori Katsuragi

    (Niigata College of Nursing)

  • Masahiko Takahashi

    (Niigata University Graduate School of Medical and Dental Sciences)

  • Masaya Higuchi

    (Kanazawa Medical University School of Medicine)

  • Tomotake Kanki

    (Niigata University Graduate School of Medical and Dental Sciences)

  • Akihiko Saitoh

    (Niigata University Graduate School of Medical and Dental Sciences)

  • Masahiro Fujii

    (Niigata University Graduate School of Medical and Dental Sciences)

Abstract

Human parechovirus (PeV-A) is an RNA virus that belongs to the family Picornaviridae and it is currently classified into 19 genotypes. PeV-As usually cause mild illness in children and adults. Among the genotypes, PeV-A3 can cause severe diseases in neonates and young infants, resulting in neurological sequelae and death. In this study, we identify the human myeloid-associated differentiation marker (MYADM) as an essential host factor for the entry of six PeV-As (PeV-A1 to PeV-A6), including PeV-A3. The infection of six PeV-As (PeV-A1 to PeV-A6) to human cells is abolished by knocking out the expression of MYADM. Hamster BHK-21 cells are resistant to PeV-A infection, but the expression of human MYADM in BHK-21 confers PeV-A infection and viral production. Furthermore, VP0 capsid protein of PeV-A3 interacts with one extracellular domain of human MYADM on the cell membrane of BHK-21. The identification of MYADM as an essential entry factor for PeV-As infection is expected to advance our understanding of the pathogenesis of PeV-As.

Suggested Citation

  • Kanako Watanabe & Tomoichiro Oka & Hirotaka Takagi & Sergei Anisimov & Shun-ichi Yamashita & Yoshinori Katsuragi & Masahiko Takahashi & Masaya Higuchi & Tomotake Kanki & Akihiko Saitoh & Masahiro Fuji, 2023. "Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37399-8
    DOI: 10.1038/s41467-023-37399-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-37399-8
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-37399-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Pamela E. Capendale & Inés García-Rodríguez & Anoop T. Ambikan & Lance A. Mulder & Josse A. Depla & Eline Freeze & Gerrit Koen & Carlemi Calitz & Vikas Sood & Renata Vieira de Sá & Ujjwal Neogi & Dasj, 2024. "Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Wenjie Qiao & Christopher M. Richards & Youlim Kim & James R. Zengel & Siyuan Ding & Harry B. Greenberg & Jan E. Carette, 2024. "MYADM binds human parechovirus 1 and is essential for viral entry," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37399-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.