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Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria

Author

Listed:
  • Andre Mu

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity
    Wellcome Sanger Institute)

  • William P. Klare

    (The University of Sydney)

  • Sarah L. Baines

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • C. N. Ignatius Pang

    (University of New South Wales
    The University of Sydney)

  • Romain Guérillot

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Nichaela Harbison-Price

    (The University of Queensland
    The University of Queensland)

  • Nadia Keller

    (The University of Queensland)

  • Jonathan Wilksch

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Nguyen Thi Khanh Nhu

    (The University of Queensland
    The University of Queensland)

  • Minh-Duy Phan

    (The University of Queensland
    The University of Queensland)

  • Bernhard Keller

    (The University of Queensland
    The University of Queensland)

  • Brunda Nijagal

    (The University of Melbourne)

  • Dedreia Tull

    (The University of Melbourne)

  • Saravanan Dayalan

    (The University of Melbourne)

  • Hwa Huat Charlie Chua

    (The University of Melbourne)

  • Dominik Skoneczny

    (The University of Melbourne)

  • Jason Koval

    (University of New South Wales)

  • Abderrahman Hachani

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Anup D. Shah

    (Monash University)

  • Nitika Neha

    (The University of Melbourne)

  • Snehal Jadhav

    (The University of Melbourne)

  • Sally R. Partridge

    (University of Sydney)

  • Amanda J. Cork

    (The University of Queensland
    The University of Queensland)

  • Kate Peters

    (The University of Queensland
    The University of Queensland)

  • Olivia Bertolla

    (The University of Queensland
    The University of Queensland)

  • Stephan Brouwer

    (The University of Queensland
    The University of Queensland)

  • Steven J. Hancock

    (The University of Queensland)

  • Laura Álvarez-Fraga

    (The University of Queensland)

  • David M. P. De Oliveira

    (The University of Queensland
    The University of Queensland)

  • Brian Forde

    (The University of Queensland)

  • Ashleigh Dale

    (The University of Sydney)

  • Warasinee Mujchariyakul

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Calum J. Walsh

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Ian Monk

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Anna Fitzgerald

    (Bioplatforms Australia Ltd.)

  • Mabel Lum

    (Bioplatforms Australia Ltd.)

  • Carolina Correa-Ospina

    (University of New South Wales)

  • Piklu Roy Chowdhury

    (University of Technology Sydney)

  • Robert G. Parton

    (The University of Queensland
    The University of Queensland)

  • James De Voss

    (The University of Queensland)

  • James Beckett

    (The University of Queensland)

  • Francois Monty

    (Australian Genome Research Facility Ltd.)

  • Jessica McKinnon

    (University of Technology Sydney)

  • Xiaomin Song

    (Macquarie University)

  • John R. Stephen

    (Australian Genome Research Facility Ltd.)

  • Marie Everest

    (Australian Genome Research Facility Ltd.)

  • Matt I. Bellgard

    (Queensland University of Technology
    Murdoch University)

  • Matthew Tinning

    (Australian Genome Research Facility Ltd.)

  • Michael Leeming

    (The University of Melbourne)

  • Dianna Hocking

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Leila Jebeli

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Nancy Wang

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Nouri Ben Zakour

    (University of Sydney)

  • Serhat A. Yasar

    (University of New South Wales)

  • Stefano Vecchiarelli

    (University of New South Wales)

  • Tonia Russell

    (University of New South Wales)

  • Thiri Zaw

    (Macquarie University)

  • Tyrone Chen

    (Monash University)

  • Don Teng

    (The University of Melbourne)

  • Zena Kassir

    (University of New South Wales)

  • Trevor Lithgow

    (Monash University)

  • Adam Jenney

    (Monash University)

  • Jason N. Cole

    (University of California at San Diego
    University of California at San Diego)

  • Victor Nizet

    (University of California at San Diego
    University of California at San Diego)

  • Tania C. Sorrell

    (University of Sydney)

  • Anton Y. Peleg

    (Monash University
    Monash University)

  • David L. Paterson

    (The University of Queensland)

  • Scott A. Beatson

    (The University of Queensland)

  • Jemma Wu

    (Macquarie University)

  • Mark P. Molloy

    (Macquarie University)

  • Anna E. Syme

    (The University of Melbourne)

  • Robert J. A. Goode

    (Monash University
    Commonwealth Scientific and Industrial Research Organisation)

  • Adam A. Hunter

    (Murdoch University)

  • Grahame Bowland

    (Murdoch University)

  • Nicholas P. West

    (The University of Queensland)

  • Marc R. Wilkins

    (University of New South Wales)

  • Steven P. Djordjevic

    (University of Technology Sydney)

  • Mark R. Davies

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Torsten Seemann

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Benjamin P. Howden

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Dana Pascovici

    (Macquarie University)

  • Sonika Tyagi

    (Monash University)

  • Ralf B. Schittenhelm

    (Monash University)

  • David P. De Souza

    (The University of Melbourne)

  • Malcolm J. McConville

    (University of Melbourne)

  • Jonathan R. Iredell

    (University of Sydney)

  • Stuart J. Cordwell

    (The University of Sydney)

  • Richard A. Strugnell

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Timothy P. Stinear

    (The University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Mark A. Schembri

    (The University of Queensland
    The University of Queensland)

  • Mark J. Walker

    (The University of Queensland
    The University of Queensland)

Abstract

Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20–40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enabling the identification of common bacterial targets for therapeutic intervention, we applied a standardized genomic, transcriptomic, proteomic and metabolomic technological framework to multiple clinical isolates of four sepsis-causing pathogens: Escherichia coli, Klebsiella pneumoniae species complex, Staphylococcus aureus and Streptococcus pyogenes. Exposure to human serum generated a sepsis molecular signature containing global increases in fatty acid and lipid biosynthesis and metabolism, consistent with cell envelope remodelling and nutrient adaptation for osmoprotection. In addition, acquisition of cholesterol was identified across the bacterial species. This detailed reference dataset has been established as an open resource to support discovery and translational research.

Suggested Citation

  • Andre Mu & William P. Klare & Sarah L. Baines & C. N. Ignatius Pang & Romain Guérillot & Nichaela Harbison-Price & Nadia Keller & Jonathan Wilksch & Nguyen Thi Khanh Nhu & Minh-Duy Phan & Bernhard Kel, 2023. "Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37200-w
    DOI: 10.1038/s41467-023-37200-w
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