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Control of human cytomegalovirus replication by liver resident natural killer cells

Author

Listed:
  • Calum Forrest

    (UCL)

  • Thomas J. G. Chase

    (UCL, Royal Free Campus)

  • Antonia O. Cuff

    (Imperial College London, Chelsea & Westminster Campus)

  • Dionas Maroulis

    (UCL, Royal Free Campus)

  • Reza Motallebzadeh

    (UCL, Royal Free Campus)

  • Amir Gander

    (UCL, Royal Free Campus)

  • Brian Davidson

    (UCL, Royal Free Campus)

  • Paul Griffiths

    (UCL)

  • Victoria Male

    (Imperial College London, Chelsea & Westminster Campus)

  • Matthew Reeves

    (UCL)

Abstract

Natural killer cells are considered to be important for control of human cytomegalovirus– a major pathogen in immune suppressed transplant patients. Viral infection promotes the development of an adaptive phenotype in circulating natural killer cells that changes their anti-viral function. In contrast, less is understood how natural killer cells that reside in tissue respond to viral infection. Here we show natural killer cells resident in the liver have an altered phenotype in cytomegalovirus infected individuals and display increased anti-viral activity against multiple viruses in vitro and identify and characterise a subset of natural killer cells responsible for control. Crucially, livers containing natural killer cells with better capacity to control cytomegalovirus replication in vitro are less likely to experience viraemia post-transplant. Taken together, these data suggest that virally induced expansion of tissue resident natural killer cells in the donor organ can reduce the chance of viraemia post-transplant.

Suggested Citation

  • Calum Forrest & Thomas J. G. Chase & Antonia O. Cuff & Dionas Maroulis & Reza Motallebzadeh & Amir Gander & Brian Davidson & Paul Griffiths & Victoria Male & Matthew Reeves, 2023. "Control of human cytomegalovirus replication by liver resident natural killer cells," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37181-w
    DOI: 10.1038/s41467-023-37181-w
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    References listed on IDEAS

    as
    1. Joseph C. Sun & Joshua N. Beilke & Lewis L. Lanier, 2009. "Erratum: Adaptive immune features of natural killer cells," Nature, Nature, vol. 457(7233), pages 1168-1168, February.
    2. Joseph C. Sun & Joshua N. Beilke & Lewis L. Lanier, 2009. "Adaptive immune features of natural killer cells," Nature, Nature, vol. 457(7229), pages 557-561, January.
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