IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-37181-w.html
   My bibliography  Save this article

Control of human cytomegalovirus replication by liver resident natural killer cells

Author

Listed:
  • Calum Forrest

    (UCL)

  • Thomas J. G. Chase

    (UCL, Royal Free Campus)

  • Antonia O. Cuff

    (Imperial College London, Chelsea & Westminster Campus)

  • Dionas Maroulis

    (UCL, Royal Free Campus)

  • Reza Motallebzadeh

    (UCL, Royal Free Campus)

  • Amir Gander

    (UCL, Royal Free Campus)

  • Brian Davidson

    (UCL, Royal Free Campus)

  • Paul Griffiths

    (UCL)

  • Victoria Male

    (Imperial College London, Chelsea & Westminster Campus)

  • Matthew Reeves

    (UCL)

Abstract

Natural killer cells are considered to be important for control of human cytomegalovirus– a major pathogen in immune suppressed transplant patients. Viral infection promotes the development of an adaptive phenotype in circulating natural killer cells that changes their anti-viral function. In contrast, less is understood how natural killer cells that reside in tissue respond to viral infection. Here we show natural killer cells resident in the liver have an altered phenotype in cytomegalovirus infected individuals and display increased anti-viral activity against multiple viruses in vitro and identify and characterise a subset of natural killer cells responsible for control. Crucially, livers containing natural killer cells with better capacity to control cytomegalovirus replication in vitro are less likely to experience viraemia post-transplant. Taken together, these data suggest that virally induced expansion of tissue resident natural killer cells in the donor organ can reduce the chance of viraemia post-transplant.

Suggested Citation

  • Calum Forrest & Thomas J. G. Chase & Antonia O. Cuff & Dionas Maroulis & Reza Motallebzadeh & Amir Gander & Brian Davidson & Paul Griffiths & Victoria Male & Matthew Reeves, 2023. "Control of human cytomegalovirus replication by liver resident natural killer cells," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37181-w
    DOI: 10.1038/s41467-023-37181-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-37181-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-37181-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Joseph C. Sun & Joshua N. Beilke & Lewis L. Lanier, 2009. "Erratum: Adaptive immune features of natural killer cells," Nature, Nature, vol. 457(7233), pages 1168-1168, February.
    2. Joseph C. Sun & Joshua N. Beilke & Lewis L. Lanier, 2009. "Adaptive immune features of natural killer cells," Nature, Nature, vol. 457(7229), pages 557-561, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sonwabile Dzanibe & Aaron J. Wilk & Susan Canny & Thanmayi Ranganath & Berenice Alinde & Florian Rubelt & Huang Huang & Mark M. Davis & Susan P. Holmes & Heather B. Jaspan & Catherine A. Blish & Clive, 2024. "Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Carmen Rožmanić & Berislav Lisnić & Marina Pribanić Matešić & Andrea Mihalić & Lea Hiršl & Eugene Park & Ana Lesac Brizić & Daniela Indenbirken & Ina Viduka & Marina Šantić & Barbara Adler & Wayne M. , 2023. "Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Tsukasa Nabekura & Elfira Amalia Deborah & Saeko Tahara & Yuya Arai & Paul E. Love & Koichiro Kako & Akiyoshi Fukamizu & Masafumi Muratani & Akira Shibuya, 2023. "Themis2 regulates natural killer cell memory function and formation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37181-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.