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An aptamer-based depot system for sustained release of small molecule therapeutics

Author

Listed:
  • Dali Wang

    (Harvard Medical School
    Harvard Medical School)

  • Yang Li

    (Harvard Medical School)

  • Xiaoran Deng

    (Harvard Medical School)

  • Matthew Torre

    (Harvard Medical School)

  • Zipei Zhang

    (Harvard Medical School)

  • Xiyu Li

    (Harvard Medical School)

  • Wei Zhang

    (Harvard Medical School)

  • Kathleen Cullion

    (Harvard Medical School)

  • Daniel S. Kohane

    (Harvard Medical School)

  • Christopher B. Weldon

    (Harvard Medical School
    Harvard Medical School
    Harvard Medical School)

Abstract

Delivery of hydrophilic small molecule therapeutics by traditional drug delivery systems is challenging. Herein, we have used the specific interaction between DNA aptamers and drugs to create simple and effective drug depot systems. The specific binding of a phosphorothioate-modified aptamer to drugs formed non-covalent aptamer/drug complexes, which created a sustained release system. We demonstrated the effectiveness of this system with small hydrophilic molecules, the site 1 sodium channel blockers tetrodotoxin and saxitoxin. The aptamer-based delivery system greatly prolonged the duration of local anesthesia and reduced systemic toxicity. The beneficial effects of the aptamers were restricted to the compounds they were specific to. These studies establish aptamers as a class of highly specific, modifiable drug delivery systems, and demonstrate potential usefulness in the management of postoperative pain.

Suggested Citation

  • Dali Wang & Yang Li & Xiaoran Deng & Matthew Torre & Zipei Zhang & Xiyu Li & Wei Zhang & Kathleen Cullion & Daniel S. Kohane & Christopher B. Weldon, 2023. "An aptamer-based depot system for sustained release of small molecule therapeutics," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37002-0
    DOI: 10.1038/s41467-023-37002-0
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    References listed on IDEAS

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    1. Chao Zhao & Andong Liu & Claudia M. Santamaria & Andre Shomorony & Tianjiao Ji & Tuo Wei & Akiva Gordon & Hannes Elofsson & Manisha Mehta & Rong Yang & Daniel S. Kohane, 2019. "Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    2. Christopher P. Rusconi & Elizabeth Scardino & Juliana Layzer & George A. Pitoc & Thomas L. Ortel & Dougald Monroe & Bruce A. Sullenger, 2002. "RNA aptamers as reversible antagonists of coagulation factor IXa," Nature, Nature, vol. 419(6902), pages 90-94, September.
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    Cited by:

    1. Xiankui Xu & Dawei Xu & Shen Lu & Xue Zhou & Shenbo Yang & Zhonghai Zhang, 2024. "Atomically dispersed recognition unit for selective in vivo photoelectrochemical medicine detection," Nature Communications, Nature, vol. 15(1), pages 1-10, December.

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