IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-36581-2.html
   My bibliography  Save this article

Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease

Author

Listed:
  • Junhua Xu

    (Indiana University
    Biopharmaceutical Research Institute, West China Hospital, Sichuan University)

  • Hongwei Cai

    (Indiana University)

  • Zhuhao Wu

    (Indiana University)

  • Xiang Li

    (Indiana University)

  • Chunhui Tian

    (Indiana University)

  • Zheng Ao

    (Indiana University)

  • Vivian C. Niu

    (Indiana University
    Bloomington High School South)

  • Xiao Xiao

    (University of California, Los Angeles)

  • Lei Jiang

    (Indiana University)

  • Marat Khodoun

    (University of Cincinnati)

  • Marc Rothenberg

    (University of Cincinnati)

  • Ken Mackie

    (Indiana University)

  • Jun Chen

    (University of California, Los Angeles)

  • Luke P. Lee

    (Brigham and Women’s Hospital, Harvard Medical School
    University of California at Berkeley
    Sungkyunkwan University)

  • Feng Guo

    (Indiana University)

Abstract

Transdermal drug delivery provides convenient and pain-free self-administration for personalized therapy. However, challenges remain in treating acute diseases mainly due to their inability to timely administrate therapeutics and precisely regulate pharmacokinetics within a short time window. Here we report the development of active acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand acute disease management. Through the integration of active acoustic metamaterials, a compact therapeutic patch is integrated for penetration of skin stratum corneum and active percutaneous transport of therapeutics with precise control of dose and rate over time. Moreover, the patch device quantitatively regulates the dosage and release kinetics of therapeutics and achieves better delivery performance in vivo than through subcutaneous injection. As a proof-of-concept application, we show our method can reverse life-threatening acute allergic reactions in a female mouse model of anaphylaxis via a multi-burst delivery of epinephrine, showing better efficacy than a fixed dosage injection of epinephrine, which is the current gold standard ‘self-injectable epinephrine’ strategy. This innovative method may provide a promising means to manage acute disease for personalized medicine.

Suggested Citation

  • Junhua Xu & Hongwei Cai & Zhuhao Wu & Xiang Li & Chunhui Tian & Zheng Ao & Vivian C. Niu & Xiao Xiao & Lei Jiang & Marat Khodoun & Marc Rothenberg & Ken Mackie & Jun Chen & Luke P. Lee & Feng Guo, 2023. "Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36581-2
    DOI: 10.1038/s41467-023-36581-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-36581-2
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-36581-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Simon Makin, 2019. "The emerging world of digital therapeutics," Nature, Nature, vol. 573(7775), pages 106-109, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ze-Qi Lu & Long Zhao & Hai-Ling Fu & Eric Yeatman & Hu Ding & Li-Qun Chen, 2024. "Ocean wave energy harvesting with high energy density and self-powered monitoring system," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ali Sunyaev & Daniel Fürstenau & Elizabeth Davidson, 2022. "Call for Papers, Issue 3/2024," Business & Information Systems Engineering: The International Journal of WIRTSCHAFTSINFORMATIK, Springer;Gesellschaft für Informatik e.V. (GI), vol. 64(4), pages 543-545, August.
    2. Ali Sunyaev & Daniel Fürstenau & Elizabeth Davidson, 2024. "Reimagining Digital Health," Business & Information Systems Engineering: The International Journal of WIRTSCHAFTSINFORMATIK, Springer;Gesellschaft für Informatik e.V. (GI), vol. 66(3), pages 249-260, June.
    3. Daniel Fürstenau & Martin Gersch & Stefanie Schreiter, 2023. "Digital Therapeutics (DTx)," Business & Information Systems Engineering: The International Journal of WIRTSCHAFTSINFORMATIK, Springer;Gesellschaft für Informatik e.V. (GI), vol. 65(3), pages 349-360, June.
    4. Helena M. Müller & Melanie Reuter-Oppermann, 2024. "Designing Behavior Change Support Systems Targeting Blood Donation Behavior," Business & Information Systems Engineering: The International Journal of WIRTSCHAFTSINFORMATIK, Springer;Gesellschaft für Informatik e.V. (GI), vol. 66(3), pages 299-319, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36581-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.