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Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life

Author

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  • Ousseny Zerbo

    (Kaiser Permanente Northern California, Vaccine Study Center)

  • G. Thomas Ray

    (Kaiser Permanente Northern California, Vaccine Study Center)

  • Bruce Fireman

    (Kaiser Permanente Northern California, Vaccine Study Center)

  • Evan Layefsky

    (Kaiser Permanente Northern California, Vaccine Study Center)

  • Kristin Goddard

    (Kaiser Permanente Northern California, Vaccine Study Center)

  • Edwin Lewis

    (Kaiser Permanente Northern California, Vaccine Study Center)

  • Pat Ross

    (Kaiser Permanente Northern California, Vaccine Study Center)

  • Saad Omer

    (Yale University, Institute for Global Health
    Yale School of Medicine
    Yale School of Public Health)

  • Mara Greenberg

    (Kaiser Permanente Northern California Oakland
    Kaiser Permanente Northern California)

  • Nicola P. Klein

    (Kaiser Permanente Northern California, Vaccine Study Center)

Abstract

We examined the effectiveness of maternal vaccination against SARS-CoV-2 infection in 30,311 infants born at Kaiser Permanente Northern California from December 15, 2020, to May 31, 2022. Using Cox regression, the effectiveness of ≥2 doses of COVID-19 vaccine received during pregnancy was 84% (95% confidence interval [CI]: 66, 93), 62% (CI: 39, 77) and 56% (CI: 34,71) during months 0–2, 0–4 and 0- 6 of a child’s life, respectively, in the Delta variant period. In the Omicron variant period, the effectiveness of maternal vaccination in these three age intervals was 21% (CI: −21,48), 14% (CI: −9,32) and 13% (CI: −3,26), respectively. Over the entire study period, the incidence of hospitalization for COVID-19 was lower during the first 6 months of life among infants of vaccinated mothers compared with infants of unvaccinated mothers (21/100,000 person-years vs. 100/100,000 person-years). Maternal vaccination was protective, but protection was lower during Omicron than during Delta. Protection during both periods decreased as infants aged.

Suggested Citation

  • Ousseny Zerbo & G. Thomas Ray & Bruce Fireman & Evan Layefsky & Kristin Goddard & Edwin Lewis & Pat Ross & Saad Omer & Mara Greenberg & Nicola P. Klein, 2023. "Maternal SARS-CoV-2 vaccination and infant protection against SARS-CoV-2 during the first six months of life," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36547-4
    DOI: 10.1038/s41467-023-36547-4
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