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Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England

Author

Listed:
  • Vahé Nafilyan

    (Office for National Statistics
    London School of Hygiene and Tropical Medicine)

  • Charlotte R. Bermingham

    (Office for National Statistics)

  • Isobel L. Ward

    (Office for National Statistics)

  • Jasper Morgan

    (Office for National Statistics)

  • Francesco Zaccardi

    (University of Leicester)

  • Kamlesh Khunti

    (University of Leicester)

  • Julie Stanborough

    (Office for National Statistics)

  • Amitava Banerjee

    (University College London)

  • James C. Doidge

    (London School of Hygiene and Tropical Medicine
    Intensive Care National Audit and Research Centre)

Abstract

Several studies have reported associations between COVID-19 vaccination and risk of cardiac diseases, especially in young people; the impact on mortality, however, remains unclear. We use national, linked electronic health data in England to assess the impact of COVID-19 vaccination and positive SARS-CoV-2 tests on the risk of cardiac and all-cause mortality in young people (12 to 29 years) using a self-controlled case series design. Here, we show there is no significant increase in cardiac or all-cause mortality in the 12 weeks following COVID-19 vaccination compared to more than 12 weeks after any dose. However, we find an increase in cardiac death in women after a first dose of non mRNA vaccines. A positive SARS-CoV-2 test is associated with increased cardiac and all-cause mortality among people vaccinated or unvaccinated at time of testing.

Suggested Citation

  • Vahé Nafilyan & Charlotte R. Bermingham & Isobel L. Ward & Jasper Morgan & Francesco Zaccardi & Kamlesh Khunti & Julie Stanborough & Amitava Banerjee & James C. Doidge, 2023. "Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36494-0
    DOI: 10.1038/s41467-023-36494-0
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    References listed on IDEAS

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    1. Colin R. Simpson & Steven Kerr & Srinivasa Vittal Katikireddi & Colin McCowan & Lewis D. Ritchie & Jiafeng Pan & Sarah J. Stock & Igor Rudan & Ruby S. M. Tsang & Simon Lusignan & F. D. Richard Hobbs &, 2022. "Second-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland," Nature Communications, Nature, vol. 13(1), pages 1-7, December.
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