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Noninvasive electromyometrial imaging of human uterine maturation during term labor

Author

Listed:
  • Hui Wang

    (Washington University
    Washington University School of Medicine
    Washington University School of Medicine)

  • Zichao Wen

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Wenjie Wu

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University)

  • Zhexian Sun

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University)

  • Zulfia Kisrieva-Ware

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Yiqi Lin

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University)

  • Sicheng Wang

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University)

  • Hansong Gao

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University)

  • Haonan Xu

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Peinan Zhao

    (Washington University School of Medicine)

  • Qing Wang

    (Washington University School of Medicine)

  • George A. Macones

    (The University of Texas at Austin)

  • Alan L. Schwartz

    (Washington University School of Medicine)

  • Phillip Cuculich

    (Washington University School of Medicine)

  • Alison G. Cahill

    (The University of Texas at Austin)

  • Yong Wang

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University
    Washington University)

Abstract

Electromyometrial imaging (EMMI) was recently developed to image the three-dimensional (3D) uterine electrical activation during contractions noninvasively and accurately in sheep. Herein we describe the development and application of a human EMMI system to image and evaluate 3D uterine electrical activation patterns at high spatial and temporal resolution during human term labor. We demonstrate the successful integration of the human EMMI system during subjects’ clinical visits to generate noninvasively the uterine surface electrical potential maps, electrograms, and activation sequence through an inverse solution using up to 192 electrodes distributed around the abdomen surface. Quantitative indices, including the uterine activation curve, are developed and defined to characterize uterine surface contraction patterns. We thus show that the human EMMI system can provide detailed 3D images and quantification of uterine contractions as well as novel insights into the role of human uterine maturation during labor progression.

Suggested Citation

  • Hui Wang & Zichao Wen & Wenjie Wu & Zhexian Sun & Zulfia Kisrieva-Ware & Yiqi Lin & Sicheng Wang & Hansong Gao & Haonan Xu & Peinan Zhao & Qing Wang & George A. Macones & Alan L. Schwartz & Phillip Cu, 2023. "Noninvasive electromyometrial imaging of human uterine maturation during term labor," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36440-0
    DOI: 10.1038/s41467-023-36440-0
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