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JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos

Author

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  • Katerina Karkali

    (Parc Cientific de Barcelona
    National University of Singapore
    BSRC Alexander Fleming)

  • Timothy E. Saunders

    (National University of Singapore
    University of Warwick)

  • George Panayotou

    (BSRC Alexander Fleming)

  • Enrique Martín-Blanco

    (Parc Cientific de Barcelona
    National University of Singapore)

Abstract

Morphogenesis of the Central Nervous System (CNS) is a complex process that obeys precise architectural rules. Yet, the mechanisms dictating these rules remain unknown. Analyzing morphogenesis of the Drosophila embryo Ventral Nerve Cord (VNC), we observe that a tight control of JNK signaling is essential for attaining the final VNC architecture. JNK signaling in a specific subset of pioneer neurons autonomously regulates the expression of Fasciclin 2 (Fas 2) and Neurexin IV (Nrx IV) adhesion molecules, probably via the transcription factor zfh1. Interfering at any step in this cascade affects fasciculation along pioneer axons, leading to secondary cumulative scaffolding defects during the structural organization of the axonal network. The global disorder of architectural landmarks ultimately influences nervous system condensation. In summary, our data point to JNK signaling in a subset of pioneer neurons as a key element underpinning VNC architecture, revealing critical milestones on the mechanism of control of its structural organization.

Suggested Citation

  • Katerina Karkali & Timothy E. Saunders & George Panayotou & Enrique Martín-Blanco, 2023. "JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36388-1
    DOI: 10.1038/s41467-023-36388-1
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    References listed on IDEAS

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    1. Takashi Adachi-Yamada & Konomi Fujimura-Kamada & Yasuyoshi Nishida & Kunihiro Matsumoto, 1999. "Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing," Nature, Nature, vol. 400(6740), pages 166-169, July.
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    Cited by:

    1. Katerina Karkali & Samuel W. Vernon & Richard A. Baines & George Panayotou & Enrique Martín-Blanco, 2023. "Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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