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A two-faced selectivity solution to target SMARCA2 for cancer therapy

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  • John D. Harling

    (Dept. of Medicinal Chemistry, GSK)

  • Christopher P. Tinworth

    (Dept. of Medicinal Chemistry, GSK)

Abstract

Two new studies exploring PROTAC-mediated degradation of SMARCA2 for cancer therapy solve an apparently intractable selectivity challenge with SMARCA4 by utilising the requirement for a productive ternary complex between the protein, PROTAC and ligase complex.

Suggested Citation

  • John D. Harling & Christopher P. Tinworth, 2023. "A two-faced selectivity solution to target SMARCA2 for cancer therapy," Nature Communications, Nature, vol. 14(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36238-0
    DOI: 10.1038/s41467-023-36238-0
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    as
    1. Jennifer Cantley & Xiaofen Ye & Emma Rousseau & Tom Januario & Brian D. Hamman & Christopher M. Rose & Tommy K. Cheung & Trent Hinkle & Leofal Soto & Connor Quinn & Alicia Harbin & Elizabeth Bortolon , 2022. "Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
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