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Timing and cell specificity of senescence drives postnatal lung development and injury

Author

Listed:
  • Hongwei Yao

    (Brown University)

  • Joselynn Wallace

    (Brown University)

  • Abigail L. Peterson

    (Brown University)

  • Alejandro Scaffa

    (Brown University)

  • Salu Rizal

    (Brown University)

  • Katy Hegarty

    (Brown University)

  • Hajime Maeda

    (Brown University)

  • Jason L. Chang

    (Brown University)

  • Nathalie Oulhen

    (Brown University)

  • Jill A. Kreiling

    (Brown University)

  • Kelsey E. Huntington

    (Brown University)

  • Monique E. Paepe

    (Women and Infants Hospital)

  • Guilherme Barbosa

    (Brown University)

  • Phyllis A. Dennery

    (Brown University
    Warren Alpert Medical School of Brown University)

Abstract

Senescence causes age-related diseases and stress-related injury. Paradoxically, it is also essential for organismal development. Whether senescence contributes to lung development or injury in early life remains unclear. Here, we show that lung senescence occurred at birth and decreased throughout the saccular stage in mice. Reducing senescent cells at this stage disrupted lung development. In mice (

Suggested Citation

  • Hongwei Yao & Joselynn Wallace & Abigail L. Peterson & Alejandro Scaffa & Salu Rizal & Katy Hegarty & Hajime Maeda & Jason L. Chang & Nathalie Oulhen & Jill A. Kreiling & Kelsey E. Huntington & Moniqu, 2023. "Timing and cell specificity of senescence drives postnatal lung development and injury," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35985-4
    DOI: 10.1038/s41467-023-35985-4
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    References listed on IDEAS

    as
    1. Corina Amor & Judith Feucht & Josef Leibold & Yu-Jui Ho & Changyu Zhu & Direna Alonso-Curbelo & Jorge Mansilla-Soto & Jacob A. Boyer & Xiang Li & Theodoros Giavridis & Amanda Kulick & Shauna Houlihan , 2020. "Senolytic CAR T cells reverse senescence-associated pathologies," Nature, Nature, vol. 583(7814), pages 127-132, July.
    2. F. M. Feringa & J. A. Raaijmakers & M. A. Hadders & C. Vaarting & L. Macurek & L. Heitink & L. Krenning & R. H. Medema, 2018. "Persistent repair intermediates induce senescence," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    Full references (including those not matched with items on IDEAS)

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