IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-022-35719-y.html
   My bibliography  Save this article

An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis

Author

Listed:
  • Noelle A. Sterling

    (Temple University
    Temple University)

  • Jun Young Park

    (Temple University)

  • Raehee Park

    (Temple University)

  • Seo-Hee Cho

    (Thomas Jefferson University)

  • Seonhee Kim

    (Temple University)

Abstract

Entosis is cell cannibalism utilized by tumor cells to engulf live neighboring cells for pro- or anti-tumorigenic purposes. It is unknown whether this extraordinary cellular event can be pathogenic in other diseases such as microcephaly, a condition characterized by a smaller than normal brain at birth. We find that mice mutant for the human microcephaly-causing gene Pals1, which exhibit diminished cortices due to massive cell death, also exhibit nuclei enveloped by plasma membranes inside of dividing cells. These cell-in-cell (CIC) structures represent a dynamic process accompanied by lengthened mitosis and cytokinesis abnormalities. As shown in tumor cells, ROCK inhibition completely abrogates CIC structures and restores the normal length of mitosis. Moreover, genetic elimination of Trp53 produces a remarkable rescue of cortical size along with substantial reductions of CIC structures and cell death. These results provide a novel pathogenic mechanism by which microcephaly is produced through entotic cell cannibalism.

Suggested Citation

  • Noelle A. Sterling & Jun Young Park & Raehee Park & Seo-Hee Cho & Seonhee Kim, 2023. "An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35719-y
    DOI: 10.1038/s41467-022-35719-y
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-35719-y
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-35719-y?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Hannah L. Mackay & David Moore & Callum Hall & Nicolai J. Birkbak & Mariam Jamal-Hanjani & Saadia A. Karim & Vinaya M. Phatak & Lucia Piñon & Jennifer P. Morton & Charles Swanton & John Quesne & Patri, 2018. "Publisher Correction: Genomic instability in mutant p53 cancer cells upon entotic engulfment," Nature Communications, Nature, vol. 9(1), pages 1-1, December.
    2. Hannah L. Mackay & David Moore & Callum Hall & Nicolai J. Birkbak & Mariam Jamal-Hanjani & Saadia A. Karim & Vinaya M. Phatak & Lucia Piñon & Jennifer P. Morton & Charles Swanton & John Quesne & Patri, 2018. "Genomic instability in mutant p53 cancer cells upon entotic engulfment," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35719-y. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.