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Effects of tuberculosis and/or HIV-1 infection on COVID-19 presentation and immune response in Africa

Author

Listed:
  • Elsa du Bruyn

    (University of Cape Town
    University of Cape Town)

  • Cari Stek

    (University of Cape Town
    University of Cape Town
    Imperial College London)

  • Remi Daroowala

    (University of Cape Town
    University of Cape Town
    Imperial College London)

  • Qonita Said-Hartley

    (University of Cape Town)

  • Marvin Hsiao

    (University of Cape Town
    National Health Laboratory Service, Groote Schuur Complex, Department of Clinical Virology)

  • Georgia Schafer

    (University of Cape Town
    University of Cape Town
    International Centre for Genetic Engineering and Biotechnology (ICGEB))

  • Rene T. Goliath

    (University of Cape Town)

  • Fatima Abrahams

    (University of Cape Town)

  • Amanda Jackson

    (University of Cape Town)

  • Sean Wasserman

    (University of Cape Town
    University of Cape Town)

  • Brian W. Allwood

    (Stellenbosch University and Tygerberg Hospital)

  • Angharad G. Davis

    (University of Cape Town
    The Francis Crick Institute
    University College London)

  • Rachel P.-J. Lai

    (University of Cape Town
    Imperial College London
    The Francis Crick Institute)

  • Anna K. Coussens

    (University of Cape Town
    University of Cape Town
    The Walter and Eliza Hall Institute of Medical Research)

  • Katalin A. Wilkinson

    (University of Cape Town
    University of Cape Town
    The Francis Crick Institute
    University College London)

  • Jantina de Vries

    (University of Cape Town)

  • Nicki Tiffin

    (University of Cape Town
    Western Cape Department of Health
    University of Cape Town
    University of Cape Town)

  • Maddalena Cerrone

    (University of Cape Town
    Imperial College London
    The Francis Crick Institute)

  • Ntobeko A. B. Ntusi

    (University of Cape Town
    University of Cape Town)

  • Catherine Riou

    (University of Cape Town
    University of Cape Town)

  • Robert J. Wilkinson

    (University of Cape Town
    University of Cape Town
    Imperial College London
    The Francis Crick Institute)

Abstract

Few studies from Africa have described the clinical impact of co-infections on SARS-CoV-2 infection. Here, we investigate the presentation and outcome of SARS-CoV-2 infection in an African setting of high HIV-1 and tuberculosis prevalence by an observational case cohort of SARS-CoV-2 patients. A comparator group of non SARS-CoV-2 participants is included. The study includes 104 adults with SARS-CoV-2 infection of whom 29.8% are HIV-1 co-infected. Two or more co-morbidities are present in 57.7% of participants, including HIV-1 (30%) and active tuberculosis (14%). Amongst patients dually infected by tuberculosis and SARS-CoV-2, clinical features can be typical of either SARS-CoV-2 or tuberculosis: lymphopenia is exacerbated, and some markers of inflammation (D-dimer and ferritin) are further elevated (p

Suggested Citation

  • Elsa du Bruyn & Cari Stek & Remi Daroowala & Qonita Said-Hartley & Marvin Hsiao & Georgia Schafer & Rene T. Goliath & Fatima Abrahams & Amanda Jackson & Sean Wasserman & Brian W. Allwood & Angharad G., 2023. "Effects of tuberculosis and/or HIV-1 infection on COVID-19 presentation and immune response in Africa," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35689-1
    DOI: 10.1038/s41467-022-35689-1
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    Cited by:

    1. Matthew J. Cummings & Barnabas Bakamutumaho & Julius J. Lutwama & Nicholas Owor & Xiaoyu Che & Maider Astorkia & Thomas S. Postler & John Kayiwa & Jocelyn Kiconco & Moses Muwanga & Christopher Nsereko, 2024. "COVID-19 immune signatures in Uganda persist in HIV co-infection and diverge by pandemic phase," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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