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Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury

Author

Listed:
  • Quentin Sastourné-Arrey

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

  • Maxime Mathieu

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

  • Xavier Contreras

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

  • Sylvie Monferran

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

  • Virginie Bourlier

    (INSERM /Paul Sabatier University UMR 1297, Team MetaDiab)

  • Marta Gil-Ortega

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

  • Enda Murphy

    (Dublin City University)

  • Claire Laurens

    (INSERM /Paul Sabatier University UMR 1297, Team MetaDiab)

  • Audrey Varin

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

  • Christophe Guissard

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

  • Corinne Barreau

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

  • Mireille André

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

  • Noémie Juin

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

  • Marie Marquès

    (INSERM /Paul Sabatier University UMR 1297, Team MetaDiab)

  • Benoit Chaput

    (Toulouse University Hospital)

  • Cédric Moro

    (INSERM /Paul Sabatier University UMR 1297, Team MetaDiab)

  • Donal O’Gorman

    (Dublin City University)

  • Louis Casteilla

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

  • Amandine Girousse

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

  • Coralie Sengenès

    (Université de Toulouse, INSERM, CNRS, EFS, ENVT, Université P. Sabatier)

Abstract

Fibro-adipogenic progenitors (FAPs) play a crucial role in skeletal muscle regeneration, as they generate a favorable niche that allows satellite cells to perform efficient muscle regeneration. After muscle injury, FAP content increases rapidly within the injured muscle, the origin of which has been attributed to their proliferation within the muscle itself. However, recent single-cell RNAseq approaches have revealed phenotype and functional heterogeneity in FAPs, raising the question of how this differentiation of regenerative subtypes occurs. Here we report that FAP-like cells residing in subcutaneous adipose tissue (ScAT), the adipose stromal cells (ASCs), are rapidly released from ScAT in response to muscle injury. Additionally, we find that released ASCs infiltrate the damaged muscle, via a platelet-dependent mechanism and thus contribute to the FAP heterogeneity. Moreover, we show that either blocking ASCs infiltration or removing ASCs tissue source impair muscle regeneration. Collectively, our data reveal that ScAT is an unsuspected physiological reservoir of regenerative cells that support skeletal muscle regeneration, underlining a beneficial relationship between muscle and fat.

Suggested Citation

  • Quentin Sastourné-Arrey & Maxime Mathieu & Xavier Contreras & Sylvie Monferran & Virginie Bourlier & Marta Gil-Ortega & Enda Murphy & Claire Laurens & Audrey Varin & Christophe Guissard & Corinne Barr, 2023. "Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35524-7
    DOI: 10.1038/s41467-022-35524-7
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    References listed on IDEAS

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    1. Barbora Malecova & Sole Gatto & Usue Etxaniz & Magda Passafaro & Amy Cortez & Chiara Nicoletti & Lorenzo Giordani & Alessio Torcinaro & Marco Bardi & Silvio Bicciato & Francesca Santa & Luca Madaro & , 2018. "Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    2. Anders B. Klein & Trine S. Nicolaisen & Niels Ørtenblad & Kasper D. Gejl & Rasmus Jensen & Andreas M. Fritzen & Emil L. Larsen & Kristian Karstoft & Henrik E. Poulsen & Thomas Morville & Ronni E. Sahl, 2021. "Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
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