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A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma

Author

Listed:
  • Chao Zhang

    (Tianjin Medical University)

  • Hongru Shen

    (Tianjin Medical University)

  • Tielong Yang

    (Tianjin Medical University)

  • Ting Li

    (Tianjin Medical University)

  • Xinyue Liu

    (Tianjin Medical University)

  • Jin Wang

    (Tianjin Medical University
    Tianjin Academy of Traditional Chinese Medicine Affiliated hospital)

  • Zhichao Liao

    (Tianjin Medical University)

  • Junqiang Wei

    (Tianjin Medical University)

  • Jia Lu

    (Tianjin Medical University)

  • Haotian Liu

    (Tianjin Medical University)

  • Lijie Xiang

    (Tianjin Medical University)

  • Yichen Yang

    (Tianjin Medical University)

  • Meng Yang

    (Tianjin Medical University)

  • Duan Wang

    (Sichuan University)

  • Yang Li

    (Tianjin Medical University)

  • Ruwei Xing

    (Tianjin Medical University)

  • Sheng Teng

    (Tianjin Medical University)

  • Jun Zhao

    (Tianjin Medical University)

  • Yun Yang

    (Tianjin Medical University)

  • Gang Zhao

    (Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University)

  • Kexin Chen

    (Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University)

  • Xiangchun Li

    (Tianjin Medical University)

  • Jilong Yang

    (Tianjin Medical University)

Abstract

Acral melanoma is a dismal subtype of melanoma occurring in glabrous acral skin, and has a higher incidence in East Asians. We perform single-cell RNA sequencing for 63,394 cells obtained from 5 acral and 3 cutaneous melanoma samples to investigate tumor heterogeneity and immune environment. We define 5 orthogonal functional cell clusters that are involved in TGF-beta signaling, Type I interferon, Wnt signaling, Cell cycle, and Cholesterol efflux signaling. Signatures of enriched TGF-beta, Type I interferon, and cholesterol efflux signaling are significantly associated with good prognosis of melanoma. Compared with cutaneous melanoma, acral melanoma samples have significantly severe immunosuppressive state including depletion of cytotoxic CD8+ T cells, enrichment of Treg cells, and exhausted CD8+ T cells. PD1 and TIM-3 have higher expression in the exhaustive CD8+ T cells of acral melanoma. Key findings are verified in two independent validation sets. This study contributes to our better understanding of acral melanoma.

Suggested Citation

  • Chao Zhang & Hongru Shen & Tielong Yang & Ting Li & Xinyue Liu & Jin Wang & Zhichao Liao & Junqiang Wei & Jia Lu & Haotian Liu & Lijie Xiang & Yichen Yang & Meng Yang & Duan Wang & Yang Li & Ruwei Xin, 2022. "A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34877-3
    DOI: 10.1038/s41467-022-34877-3
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    Cited by:

    1. Chuanyuan Wei & Wei Sun & Kangjie Shen & Jingqin Zhong & Wanlin Liu & Zixu Gao & Yu Xu & Lu Wang & Tu Hu & Ming Ren & Yinlam Li & Yu Zhu & Shaoluan Zheng & Ming Zhu & Rongkui Luo & Yanwen Yang & Yingy, 2023. "Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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