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The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria

Author

Listed:
  • Ketsanee Srinamon

    (Mahidol University)

  • James A. Watson

    (Oxford University Clinical Research Unit, Hospital for Tropical Diseases
    University of Oxford
    WorldWide Antimalarial Resistance Network)

  • Kamolrat Silamut

    (Mahidol University)

  • Benjamas Intharabut

    (Mahidol University)

  • Nguyen Hoan Phu

    (Oxford University Clinical Research Unit, Hospital for Tropical Diseases)

  • Pham Thi Diep

    (Oxford University Clinical Research Unit, Hospital for Tropical Diseases)

  • Kirsten E. Lyke

    (University of Maryland School of Medicine)

  • Caterina Fanello

    (Mahidol University
    University of Oxford)

  • Lorenz Seidlein

    (Mahidol University
    University of Oxford)

  • Kesinee Chotivanich

    (Mahidol University)

  • Arjen M. Dondorp

    (Mahidol University
    University of Oxford)

  • Nicholas P. J. Day

    (Mahidol University
    University of Oxford)

  • Nicholas J. White

    (Mahidol University
    University of Oxford)

Abstract

Severe falciparum malaria is a major cause of death in tropical countries, particularly in African children. Rapid and accurate diagnosis and prognostic assessment are critical to clinical management. In 6027 prospectively studied patients diagnosed with severe malaria we assess the prognostic value of peripheral blood film counts of malaria pigment containing polymorphonuclear leukocytes (PMNs) and monocytes. We combine these results with previously published data and show, in an individual patient data meta-analysis (n = 32,035), that the proportion of pigment containing PMNs is predictive of in-hospital mortality. In African children the proportion of pigment containing PMNs helps distinguish severe malaria from other life-threatening febrile illnesses, and it adds to the prognostic assessment from simple bedside examination, and to the conventional malaria parasite count. Microscopy assessment of pigment containing PMNs is simple and rapid, and should be performed in all patients hospitalised with suspected severe malaria.

Suggested Citation

  • Ketsanee Srinamon & James A. Watson & Kamolrat Silamut & Benjamas Intharabut & Nguyen Hoan Phu & Pham Thi Diep & Kirsten E. Lyke & Caterina Fanello & Lorenz Seidlein & Kesinee Chotivanich & Arjen M. D, 2022. "The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34678-8
    DOI: 10.1038/s41467-022-34678-8
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    Cited by:

    1. Aayire C. Yadem & Jillian N. Armstrong & Mustafa Sarimollaoglu & Civian Kiki Massa & Jean-Michel Ndifo & Yulian A. Menyaev & Anastasie Mbe & Kacey Richards & Martina Wade & Yushun Zeng & Ruimin Chen &, 2024. "Noninvasive in vivo photoacoustic detection of malaria with Cytophone in Cameroon," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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