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Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly

Author

Listed:
  • Peggy Riese

    (Helmholtz Centre for Infection Research (HZI))

  • Stephanie Trittel

    (Helmholtz Centre for Infection Research (HZI))

  • Manas K. Akmatov

    (TWINCORE Centre for Experimental and Clinical Infection Medicine
    Central Research Institute of Ambulatory Health Care)

  • Marcus May

    (Hannover Medical School)

  • Jana Prokein

    (Hannover Medical School)

  • Thomas Illig

    (Hannover Medical School)

  • Christoph Schindler

    (Hannover Medical School)

  • Birgit Sawitzki

    (Charité-Universitätsmedizin, Campus Virchow-Klinikum, Augustenburger Pl. 1
    Charité - Universitätsmedizin Berlin)

  • Yassin Elfaki

    (Helmholtz Centre for Infection Research (HZI))

  • Stefan Floess

    (Helmholtz Centre for Infection Research (HZI))

  • Jochen Huehn

    (Helmholtz Centre for Infection Research (HZI)
    Hannover Medical School)

  • Adrian J. Błażejewski

    (Helmholtz Centre for Infection Research (HZI))

  • Till Strowig

    (TWINCORE Centre for Experimental and Clinical Infection Medicine
    Hannover Medical School
    Helmholtz Centre for Infection Research (HZI)
    Centre for Individualised Infection Medicine (CiiM))

  • Esteban A. Hernandez-Vargas

    (University of Idaho)

  • Robert Geffers

    (RG Genome Analytics, Helmholtz Centre for Infection Research (HZI))

  • Bowen Zhang

    (Centre for Individualised Infection Medicine (CiiM)
    TWINCORE Centre for Experimental and Clinical Infection Research)

  • Yang Li

    (Centre for Individualised Infection Medicine (CiiM)
    TWINCORE Centre for Experimental and Clinical Infection Research
    Radboud University Medical Center)

  • Frank Pessler

    (TWINCORE Centre for Experimental and Clinical Infection Medicine)

  • Carlos A. Guzmán

    (Helmholtz Centre for Infection Research (HZI))

Abstract

Seasonal influenza outbreaks, especially in high-risk groups such as the elderly, represent an important public health problem. Prevailing inadequate efficacy of seasonal vaccines is a crucial bottleneck. Understanding the immunological and molecular mechanisms underpinning differential influenza vaccine responsiveness is essential to improve vaccination strategies. Here we show comprehensive characterization of the immune response of randomly selected elderly participants (≥ 65 years), immunized with the adjuvanted influenza vaccine Fluad. In-depth analyses by serology, multi-parametric flow cytometry, multiplex and transcriptome analysis, coupled to bioinformatics and mathematical modelling, reveal distinguishing immunological and molecular features between responders and non-responders defined by vaccine-induced seroconversion. Non-responders are specifically characterized by multiple suppressive immune mechanisms. The generated comprehensive high dimensional dataset enables the identification of putative mechanisms and nodes responsible for vaccine non-responsiveness independently of confounding age-related effects, with the potential to facilitate development of tailored vaccination strategies for the elderly.

Suggested Citation

  • Peggy Riese & Stephanie Trittel & Manas K. Akmatov & Marcus May & Jana Prokein & Thomas Illig & Christoph Schindler & Birgit Sawitzki & Yassin Elfaki & Stefan Floess & Jochen Huehn & Adrian J. Błażeje, 2022. "Distinct immunological and molecular signatures underpinning influenza vaccine responsiveness in the elderly," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34487-z
    DOI: 10.1038/s41467-022-34487-z
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