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Lipidomic signatures align with inflammatory patterns and outcomes in critical illness

Author

Listed:
  • Junru Wu

    (University of Pittsburgh
    Division of Trauma and Acute Care Surgery
    Central South University
    Central South University)

  • Anthony Cyr

    (University of Pittsburgh
    Division of Trauma and Acute Care Surgery)

  • Danielle S. Gruen

    (University of Pittsburgh
    Division of Trauma and Acute Care Surgery)

  • Tyler C. Lovelace

    (University of Pittsburgh
    Joint CMU-Pitt PhD Program in Computational Biology)

  • Panayiotis V. Benos

    (University of Pittsburgh)

  • Jishnu Das

    (University of Pittsburgh School of Medicine)

  • Upendra K. Kar

    (University of Pittsburgh
    Division of Trauma and Acute Care Surgery)

  • Tianmeng Chen

    (University of Pittsburgh
    University of Pittsburgh School of Medicine)

  • Francis X. Guyette

    (University of Pittsburgh)

  • Mark H. Yazer

    (The Institute for Transfusion Medicine)

  • Brian J. Daley

    (University of Tennessee Health Science Center)

  • Richard S. Miller

    (Vanderbilt University Medical Center)

  • Brian G. Harbrecht

    (University of Louisville)

  • Jeffrey A. Claridge

    (Case Western Reserve University)

  • Herb A. Phelan

    (University of Texas Southwestern)

  • Brian S. Zuckerbraun

    (University of Pittsburgh
    Division of Trauma and Acute Care Surgery)

  • Matthew D. Neal

    (University of Pittsburgh
    Division of Trauma and Acute Care Surgery)

  • Pär I. Johansson

    (Copenhagen University Hospital)

  • Jakob Stensballe

    (Copenhagen University Hospital
    Copenhagen University Hospital
    The Capital Region of Denmark)

  • Rami A. Namas

    (University of Pittsburgh
    Division of Trauma and Acute Care Surgery)

  • Yoram Vodovotz

    (University of Pittsburgh
    Division of Trauma and Acute Care Surgery)

  • Jason L. Sperry

    (University of Pittsburgh
    Division of Trauma and Acute Care Surgery)

  • Timothy R. Billiar

    (University of Pittsburgh
    Division of Trauma and Acute Care Surgery)

Abstract

Alterations in lipid metabolism have the potential to be markers as well as drivers of pathobiology of acute critical illness. Here, we took advantage of the temporal precision offered by trauma as a common cause of critical illness to identify the dynamic patterns in the circulating lipidome in critically ill humans. The major findings include an early loss of all classes of circulating lipids followed by a delayed and selective lipogenesis in patients destined to remain critically ill. The previously reported survival benefit of early thawed plasma administration was associated with preserved lipid levels that related to favorable changes in coagulation and inflammation biomarkers in causal modelling. Phosphatidylethanolamines (PE) were elevated in patients with persistent critical illness and PE levels were prognostic for worse outcomes not only in trauma but also severe COVID-19 patients. Here we show selective rise in systemic PE as a common prognostic feature of critical illness.

Suggested Citation

  • Junru Wu & Anthony Cyr & Danielle S. Gruen & Tyler C. Lovelace & Panayiotis V. Benos & Jishnu Das & Upendra K. Kar & Tianmeng Chen & Francis X. Guyette & Mark H. Yazer & Brian J. Daley & Richard S. Mi, 2022. "Lipidomic signatures align with inflammatory patterns and outcomes in critical illness," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34420-4
    DOI: 10.1038/s41467-022-34420-4
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    References listed on IDEAS

    as
    1. Nidhi Kedia-Mehta & David K. Finlay, 2019. "Competition for nutrients and its role in controlling immune responses," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
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    Cited by:

    1. Kun Zhang & Pengfei Wang & Wei Huang & Shi-Hao Tang & Hanzhong Xue & Hao Wu & Ying Zhang & Yu Rong & Shan-Shan Dong & Jia-Bin Chen & Yan Zou & Ding Tian & Na Yang & Yifan Liang & Chungui Liu & Dongyan, 2024. "Integrated landscape of plasma metabolism and proteome of patients with post-traumatic deep vein thrombosis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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