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Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders

Author

Listed:
  • M. D. Hettwer

    (Heinrich Heine University Düsseldorf
    Max Planck School of Cognition, Max Planck Institute for Human Cognitive and Brain Sciences
    Brain & Behavior (INM-7), Research Centre Jülich
    Max Planck Institute for Human Cognitive and Brain Sciences)

  • S. Larivière

    (Montreal Neurological Institute, McGill University)

  • B. Y. Park

    (Montreal Neurological Institute, McGill University
    Inha University
    Institute for Basic Science)

  • O. A. Heuvel

    (Vrije Universiteit Amsterdam, Department of Anatomy and Neuroscience and Psychiatry, Amsterdam Neuroscience)

  • L. Schmaal

    (The University of Melbourne
    Orygen)

  • O. A. Andreassen

    (University of Oslo and Oslo University Hospital)

  • C. R. K. Ching

    (Keck School of Medicine, University of Southern California)

  • M. Hoogman

    (Radboud University Medical Center)

  • J. Buitelaar

    (Radboud University Medical Center)

  • D. Rooij

    (Radboud University Medical Center)

  • D. J. Veltman

    (Vrije Universiteit Amsterdam, Department of Anatomy and Neuroscience and Psychiatry, Amsterdam Neuroscience)

  • D. J. Stein

    (University of Cape Town)

  • B. Franke

    (Radboud University Medical Center)

  • T. G. M. Erp

    (University of California Irvine, Irvine Hall
    University of California Irvine)

  • N. Jahanshad

    (Keck School of Medicine, University of Southern California)

  • P. M. Thompson

    (Keck School of Medicine, University of Southern California)

  • S. I. Thomopoulos

    (Keck School of Medicine, University of Southern California)

  • R. A. I. Bethlehem

    (University of Cambridge
    University of Cambridge)

  • B. C. Bernhardt

    (Montreal Neurological Institute, McGill University)

  • S. B. Eickhoff

    (Heinrich Heine University Düsseldorf
    Brain & Behavior (INM-7), Research Centre Jülich)

  • S. L. Valk

    (Heinrich Heine University Düsseldorf
    Brain & Behavior (INM-7), Research Centre Jülich
    Max Planck Institute for Human Cognitive and Brain Sciences)

Abstract

Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters. Manifold learning revealed frontal-to-temporal and sensory/limbic-to-occipitoparietal transdiagnostic gradients, differentiating shared illness effects on cortical thickness along these axes. The principal gradient aligned with a normative cortical thickness covariance gradient and established a transcriptomic link to cortico-cerebello-thalamic circuits. Moreover, transdiagnostic gradients segregated functional networks involved in basic sensory, attentional/perceptual, and domain-general cognitive processes, and distinguished between regional cytoarchitectonic profiles. Together, our findings indicate that shared illness effects occur in a synchronized fashion and along multiple levels of hierarchical cortical organization.

Suggested Citation

  • M. D. Hettwer & S. Larivière & B. Y. Park & O. A. Heuvel & L. Schmaal & O. A. Andreassen & C. R. K. Ching & M. Hoogman & J. Buitelaar & D. Rooij & D. J. Veltman & D. J. Stein & B. Franke & T. G. M. Er, 2022. "Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34367-6
    DOI: 10.1038/s41467-022-34367-6
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    References listed on IDEAS

    as
    1. Michael Marshall, 2020. "The hidden links between mental disorders," Nature, Nature, vol. 581(7806), pages 19-21, May.
    2. Bo-yong Park & Seok-Jun Hong & Sofie L. Valk & Casey Paquola & Oualid Benkarim & Richard A. I. Bethlehem & Adriana Di Martino & Michael P. Milham & Alessandro Gozzi & B. T. Thomas Yeo & Jonathan Small, 2021. "Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
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    Cited by:

    1. Meike D. Hettwer & Lena Dorfschmidt & Lara M. C. Puhlmann & Linda M. Jacob & Casey Paquola & Richard A. I. Bethlehem & Edward T. Bullmore & Simon B. Eickhoff & Sofie L. Valk, 2024. "Longitudinal variation in resilient psychosocial functioning is associated with ongoing cortical myelination and functional reorganization during adolescence," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Julie Ottoy & Min Su Kang & Jazlynn Xiu Min Tan & Lyndon Boone & Reinder Vos de Wael & Bo-yong Park & Gleb Bezgin & Firoza Z. Lussier & Tharick A. Pascoal & Nesrine Rahmouni & Jenna Stevenson & Jaime , 2024. "Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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