Author
Listed:
- M. D. Hettwer
(Heinrich Heine University Düsseldorf
Max Planck School of Cognition, Max Planck Institute for Human Cognitive and Brain Sciences
Brain & Behavior (INM-7), Research Centre Jülich
Max Planck Institute for Human Cognitive and Brain Sciences)
- S. Larivière
(Montreal Neurological Institute, McGill University)
- B. Y. Park
(Montreal Neurological Institute, McGill University
Inha University
Institute for Basic Science)
- O. A. Heuvel
(Vrije Universiteit Amsterdam, Department of Anatomy and Neuroscience and Psychiatry, Amsterdam Neuroscience)
- L. Schmaal
(The University of Melbourne
Orygen)
- O. A. Andreassen
(University of Oslo and Oslo University Hospital)
- C. R. K. Ching
(Keck School of Medicine, University of Southern California)
- M. Hoogman
(Radboud University Medical Center)
- J. Buitelaar
(Radboud University Medical Center)
- D. Rooij
(Radboud University Medical Center)
- D. J. Veltman
(Vrije Universiteit Amsterdam, Department of Anatomy and Neuroscience and Psychiatry, Amsterdam Neuroscience)
- D. J. Stein
(University of Cape Town)
- B. Franke
(Radboud University Medical Center)
- T. G. M. Erp
(University of California Irvine, Irvine Hall
University of California Irvine)
- N. Jahanshad
(Keck School of Medicine, University of Southern California)
- P. M. Thompson
(Keck School of Medicine, University of Southern California)
- S. I. Thomopoulos
(Keck School of Medicine, University of Southern California)
- R. A. I. Bethlehem
(University of Cambridge
University of Cambridge)
- B. C. Bernhardt
(Montreal Neurological Institute, McGill University)
- S. B. Eickhoff
(Heinrich Heine University Düsseldorf
Brain & Behavior (INM-7), Research Centre Jülich)
- S. L. Valk
(Heinrich Heine University Düsseldorf
Brain & Behavior (INM-7), Research Centre Jülich
Max Planck Institute for Human Cognitive and Brain Sciences)
Abstract
Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six neurodevelopmental and psychiatric disorders, reflecting pathological structural covariance. In 12,024 patients and 18,969 controls from the ENIGMA consortium, we observed that co-alteration patterns followed normative connectome organization and were anchored to prefrontal and temporal disease epicenters. Manifold learning revealed frontal-to-temporal and sensory/limbic-to-occipitoparietal transdiagnostic gradients, differentiating shared illness effects on cortical thickness along these axes. The principal gradient aligned with a normative cortical thickness covariance gradient and established a transcriptomic link to cortico-cerebello-thalamic circuits. Moreover, transdiagnostic gradients segregated functional networks involved in basic sensory, attentional/perceptual, and domain-general cognitive processes, and distinguished between regional cytoarchitectonic profiles. Together, our findings indicate that shared illness effects occur in a synchronized fashion and along multiple levels of hierarchical cortical organization.
Suggested Citation
M. D. Hettwer & S. Larivière & B. Y. Park & O. A. Heuvel & L. Schmaal & O. A. Andreassen & C. R. K. Ching & M. Hoogman & J. Buitelaar & D. Rooij & D. J. Veltman & D. J. Stein & B. Franke & T. G. M. Er, 2022.
"Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders,"
Nature Communications, Nature, vol. 13(1), pages 1-14, December.
Handle:
RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34367-6
DOI: 10.1038/s41467-022-34367-6
Download full text from publisher
References listed on IDEAS
- Michael Marshall, 2020.
"The hidden links between mental disorders,"
Nature, Nature, vol. 581(7806), pages 19-21, May.
- Bo-yong Park & Seok-Jun Hong & Sofie L. Valk & Casey Paquola & Oualid Benkarim & Richard A. I. Bethlehem & Adriana Di Martino & Michael P. Milham & Alessandro Gozzi & B. T. Thomas Yeo & Jonathan Small, 2021.
"Differences in subcortico-cortical interactions identified from connectome and microcircuit models in autism,"
Nature Communications, Nature, vol. 12(1), pages 1-15, December.
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Cited by:
- Meike D. Hettwer & Lena Dorfschmidt & Lara M. C. Puhlmann & Linda M. Jacob & Casey Paquola & Richard A. I. Bethlehem & Edward T. Bullmore & Simon B. Eickhoff & Sofie L. Valk, 2024.
"Longitudinal variation in resilient psychosocial functioning is associated with ongoing cortical myelination and functional reorganization during adolescence,"
Nature Communications, Nature, vol. 15(1), pages 1-15, December.
- Julie Ottoy & Min Su Kang & Jazlynn Xiu Min Tan & Lyndon Boone & Reinder Vos de Wael & Bo-yong Park & Gleb Bezgin & Firoza Z. Lussier & Tharick A. Pascoal & Nesrine Rahmouni & Jenna Stevenson & Jaime , 2024.
"Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease,"
Nature Communications, Nature, vol. 15(1), pages 1-18, December.
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