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Ligand-switchable nanoparticles resembling viral surface for sequential drug delivery and improved oral insulin therapy

Author

Listed:
  • Tiantian Yang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Aohua Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Di Nie

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Weiwei Fan

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xiaohe Jiang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Miaorong Yu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Shiyan Guo

    (Chinese Academy of Sciences)

  • Chunliu Zhu

    (Chinese Academy of Sciences)

  • Gang Wei

    (Fudan University)

  • Yong Gan

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    National Institutes for Food and Drug Control)

Abstract

Mutual interference between surface ligands on multifunctional nanoparticles remains a significant obstacle to achieving optimal drug-delivery efficacy. Here, we develop ligand-switchable nanoparticles which resemble viral unique surfaces, enabling them to fully display diverse functions. The nanoparticles are modified with a pH-responsive stretchable cell-penetrating peptide (Pep) and a liver-targeting moiety (Gal) (Pep/Gal-PNPs). Once orally administered, the acidic environments trigger the extension of Pep from surface in a virus-like manner, enabling Pep/Gal-PNPs to traverse intestinal barriers efficiently. Subsequently, Gal is exposed by Pep folding at physiological pH, thereby allowing the specific targeting of Pep/Gal-PNPs to the liver. As a proof-of-concept, insulin-loaded Pep/Gal-PNPs are fabricated which exhibit effective intestinal absorption and excellent hepatic deposition of insulin. Crucially, Pep/Gal-PNPs increase hepatic glycogen production by 7.2-fold, contributing to the maintenance of glucose homeostasis for effective diabetes management. Overall, this study provides a promising approach to achieving full potential of diverse ligands on multifunctional nanoparticles.

Suggested Citation

  • Tiantian Yang & Aohua Wang & Di Nie & Weiwei Fan & Xiaohe Jiang & Miaorong Yu & Shiyan Guo & Chunliu Zhu & Gang Wei & Yong Gan, 2022. "Ligand-switchable nanoparticles resembling viral surface for sequential drug delivery and improved oral insulin therapy," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34357-8
    DOI: 10.1038/s41467-022-34357-8
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    References listed on IDEAS

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    1. Andrés Bustamante & Juan Sotelo-Campos & Daniel G. Guerra & Martin Floor & Christian A. M. Wilson & Carlos Bustamante & Mauricio Báez, 2017. "Author Correction: The energy cost of polypeptide knot formation and its folding consequences," Nature Communications, Nature, vol. 8(1), pages 1-1, December.
    2. Miriam Colombo & Luisa Fiandra & Giulia Alessio & Serena Mazzucchelli & Manuela Nebuloni & Clara De Palma & Karsten Kantner & Beatriz Pelaz & Rany Rotem & Fabio Corsi & Wolfgang J. Parak & Davide Pros, 2016. "Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies," Nature Communications, Nature, vol. 7(1), pages 1-14, December.
    3. Meng Liu & Azzurra Apriceno & Miguel Sipin & Edoardo Scarpa & Laura Rodriguez-Arco & Alessandro Poma & Gabriele Marchello & Giuseppe Battaglia & Stefano Angioletti-Uberti, 2020. "Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    4. Andrés Bustamante & Juan Sotelo-Campos & Daniel G. Guerra & Martin Floor & Christian A. M. Wilson & Carlos Bustamante & Mauricio Báez, 2017. "The energy cost of polypeptide knot formation and its folding consequences," Nature Communications, Nature, vol. 8(1), pages 1-8, December.
    5. Xiyong Song & Yuejun Shi & Wei Ding & Tongxin Niu & Limeng Sun & Yubei Tan & Yong Chen & Jiale Shi & Qiqi Xiong & Xiaojun Huang & Shaobo Xiao & Yanping Zhu & Chongyun Cheng & Zhen F. Fu & Zhi-Jie Liu , 2021. "Cryo-EM analysis of the HCoV-229E spike glycoprotein reveals dynamic prefusion conformational changes," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
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