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A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection

Author

Listed:
  • Clara Calvert

    (University of Edinburgh
    London School of Hygiene and Tropical Medicine)

  • Jade Carruthers

    (Public Health Scotland)

  • Cheryl Denny

    (Public Health Scotland)

  • Jack Donaghy

    (Public Health Scotland)

  • Sam Hillman

    (Public Health Scotland)

  • Lisa E. M. Hopcroft

    (Public Health Scotland
    University of Oxford)

  • Leanne Hopkins

    (Public Health Scotland)

  • Anna Goulding

    (Public Health Scotland)

  • Laura Lindsay

    (Public Health Scotland)

  • Terry McLaughlin

    (Public Health Scotland)

  • Emily Moore

    (Public Health Scotland)

  • Jiafeng Pan

    (University of Strathclyde)

  • Bob Taylor

    (Public Health Scotland)

  • Fatima Almaghrabi

    (University of Edinburgh)

  • Bonnie Auyeung

    (University of Edinburgh)

  • Krishnan Bhaskaran

    (London School of Hygiene and Tropical Medicine)

  • Cheryl L. Gibbons

    (Public Health Scotland)

  • Srinivasa Vittal Katikireddi

    (Public Health Scotland
    University of Glasgow)

  • Colin McCowan

    (University of St Andrews)

  • Josie Murray

    (Public Health Scotland
    University of St Andrews)

  • Maureen O’Leary

    (Public Health Scotland)

  • Lewis D. Ritchie

    (University of Aberdeen)

  • Syed Ahmar Shah

    (University of Edinburgh)

  • Colin R. Simpson

    (Public Health Scotland
    Victoria University of Wellington)

  • Chris Robertson

    (Public Health Scotland
    University of Strathclyde)

  • Aziz Sheikh

    (University of Edinburgh)

  • Sarah J. Stock

    (University of Edinburgh
    Public Health Scotland)

  • Rachael Wood

    (University of Edinburgh
    Public Health Scotland)

Abstract

Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between COVID-19 vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. We identified women in Scotland vaccinated between 6 weeks preconception and 19 weeks 6 days gestation (for miscarriage; n = 18,780) or 2 weeks 6 days gestation (for ectopic; n = 10,570). Matched, unvaccinated women from the pre-pandemic and, separately, pandemic periods were used as controls. Here we show no association between vaccination and miscarriage (adjusted Odds Ratio [aOR], pre-pandemic controls = 1.02, 95% Confidence Interval [CI] = 0.96–1.09) or ectopic pregnancy (aOR = 1.13, 95% CI = 0.92–1.38). We undertook additional analyses examining confirmed SARS-CoV-2 infection as the exposure and similarly found no association with miscarriage or ectopic pregnancy. Our findings support current recommendations that vaccination remains the safest way for pregnant women to protect themselves and their babies from COVID-19.

Suggested Citation

  • Clara Calvert & Jade Carruthers & Cheryl Denny & Jack Donaghy & Sam Hillman & Lisa E. M. Hopcroft & Leanne Hopkins & Anna Goulding & Laura Lindsay & Terry McLaughlin & Emily Moore & Jiafeng Pan & Bob , 2022. "A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33937-y
    DOI: 10.1038/s41467-022-33937-y
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    References listed on IDEAS

    as
    1. Smriti Prasad & Erkan Kalafat & Helena Blakeway & Rosemary Townsend & Pat O’Brien & Edward Morris & Tim Draycott & Shakila Thangaratinam & Kirsty Le Doare & Shamez Ladhani & Peter von Dadelszen & Laur, 2022. "Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
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    Cited by:

    1. Laura Lindsay & Clara Calvert & Ting Shi & Jade Carruthers & Cheryl Denny & Jack Donaghy & Lisa E. M. Hopcroft & Leanne Hopkins & Anna Goulding & Terry McLaughlin & Emily Moore & Bob Taylor & Krishnan, 2023. "Neonatal and maternal outcomes following SARS-CoV-2 infection and COVID-19 vaccination: a population-based matched cohort study," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Clara Calvert & Jade Carruthers & Cheryl Denny & Jack Donaghy & Lisa E. M. Hopcroft & Leanne Hopkins & Anna Goulding & Laura Lindsay & Terry McLaughlin & Emily Moore & Bob Taylor & Maria Loane & Helen, 2023. "A population-based matched cohort study of major congenital anomalies following COVID-19 vaccination and SARS-CoV-2 infection," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

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