IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-33827-3.html
   My bibliography  Save this article

[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes

Author

Listed:
  • Rachel C. Epplin

    (Indiana University)

  • Shashwati Paul

    (Indiana University)

  • Loïc Herter

    (SpiroChem AG)

  • Christophe Salome

    (SpiroChem AG)

  • Erin N. Hancock

    (Indiana University
    Corteva Agriscience)

  • Jay F. Larrow

    (Novartis Institutes for BioMedical Research
    Relay Therapeutics)

  • Erich W. Baum

    (Novartis Institutes for BioMedical Research
    Relay Therapeutics)

  • David R. Dunstan

    (Novartis Institutes for BioMedical Research
    Relay Therapeutics)

  • Carol Ginsburg-Moraff

    (Novartis Institutes for BioMedical Research)

  • Thomas C. Fessard

    (SpiroChem AG)

  • M. Kevin Brown

    (Indiana University)

Abstract

Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable drug discovery. Herein we disclose [2]-ladderanes as a class of meta-substituted aromatic ring isosteres and rigidified cyclohexanes. A straightforward synthesis of the building blocks is presented along with representative derivatization. Preliminary studies reveal that the [2]-ladderanes offer similar metabolic and physicochemical properties thus establishing this class of molecules as interesting motifs.

Suggested Citation

  • Rachel C. Epplin & Shashwati Paul & Loïc Herter & Christophe Salome & Erin N. Hancock & Jay F. Larrow & Erich W. Baum & David R. Dunstan & Carol Ginsburg-Moraff & Thomas C. Fessard & M. Kevin Brown, 2022. "[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes," Nature Communications, Nature, vol. 13(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33827-3
    DOI: 10.1038/s41467-022-33827-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-33827-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-33827-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33827-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.