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ChAd155-RSV vaccine is immunogenic and efficacious against bovine RSV infection-induced disease in young calves

Author

Listed:
  • Rineke Jong

    (Wageningen Bioveterinary Research, Wageningen University & Research)

  • Norbert Stockhofe-Zurwieden

    (Wageningen Bioveterinary Research, Wageningen University & Research)

  • Judith Bonsing

    (Wageningen Bioveterinary Research, Wageningen University & Research)

  • Kai-Fen Wang

    (GSK
    Atara Biotherapeutics, Inc.)

  • Sarah Vandepaer

    (CONSULTYS Benelux S.A)

  • Badiaa Bouzya

    (GSK, Rue de l’Institut 89)

  • Jean-François Toussaint

    (GSK, Rue de l’Institut 89
    Sanofi-Pasteur, 14 Espace Henry Vallée)

  • Ilse Dieussaert

    (GSK, Rue de l’Institut 89)

  • Haifeng Song

    (GSK
    Suzhou Abogen Bioscience Ltd)

  • Ann-Muriel Steff

    (GSK)

Abstract

Respiratory syncytial virus (RSV) infection causes a substantial lower-respiratory-tract disease burden in infants, constituting a global priority for vaccine development. We evaluated immunogenicity, safety and efficacy of a chimpanzee adenovirus (ChAd)-based vaccine candidate, ChAd155-RSV, in a bovine RSV (bRSV) challenge model. This model closely reproduces the pathogenesis/clinical manifestations of severe pediatric RSV disease. In seronegative calves, ChAd155-RSV elicits robust neutralizing antibody responses against human RSV. Two doses protect calves from clinical symptoms/lung pathological changes, and reduce nasal/lung virus loads after both a short (4-week) and a long (16-week) interval between last immunization and subsequent bRSV challenge. The one-dose regimen confers near-complete or significant protection after short-term or long-term intervals before challenge, respectively. The presence of pre-existing bRSV-antibodies does not affect short-term efficacy of the two-dose regimen. Immunized calves present no clinical signs of enhanced respiratory disease. Collectively, this supports the development of ChAd155-RSV as an RSV vaccine candidate for infants.

Suggested Citation

  • Rineke Jong & Norbert Stockhofe-Zurwieden & Judith Bonsing & Kai-Fen Wang & Sarah Vandepaer & Badiaa Bouzya & Jean-François Toussaint & Ilse Dieussaert & Haifeng Song & Ann-Muriel Steff, 2022. "ChAd155-RSV vaccine is immunogenic and efficacious against bovine RSV infection-induced disease in young calves," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33649-3
    DOI: 10.1038/s41467-022-33649-3
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    References listed on IDEAS

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    1. Daiyin Tian & Michael B. Battles & Syed M. Moin & Man Chen & Kayvon Modjarrad & Azad Kumar & Masaru Kanekiyo & Kevin W. Graepel & Noor M. Taher & Anne L. Hotard & Martin L. Moore & Min Zhao & Zi-Zheng, 2017. "Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein," Nature Communications, Nature, vol. 8(1), pages 1-7, December.
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