Author
Listed:
- Hanyao Huang
(Sichuan University
Columbia University
Sichuan University)
- Weiyi Pan
(Sichuan University
Sichuan University
Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University)
- Yifan Wang
(Huazhong University of Science and Technology
Huazhong University of Science and Technology)
- Hye Sung Kim
(Columbia University
Dankook University)
- Dan Shao
(Columbia University
South China University of Technology)
- Baoding Huang
(Columbia University
Sun Yat-sen University and Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology)
- Tzu-Chieh Ho
(Columbia University)
- Yeh-Hsing Lao
(Columbia University)
- Chai Hoon Quek
(Columbia University)
- Jiayu Shi
(The University of Michigan)
- Qianming Chen
(Sichuan University
Sichuan University
Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University)
- Bing Shi
(Sichuan University
Sichuan University)
- Shengmin Zhang
(Huazhong University of Science and Technology)
- Lei Zhao
(Sichuan University
Sichuan University)
- Kam W. Leong
(Columbia University
Columbia University Medical Center)
Abstract
Periodontitis is a common type of inflammatory bone loss and a risk factor for systemic diseases. The pathogenesis of periodontitis involves inflammatory dysregulation, which represents a target for new therapeutic strategies to treat periodontitis. After establishing the correlation of cell-free DNA (cfDNA) level with periodontitis in patient samples, we test the hypothesis that the cfDNA-scavenging approach will benefit periodontitis treatment. We create a nanoparticulate cfDNA scavenger specific for periodontitis by coating selenium-doped hydroxyapatite nanoparticles (SeHANs) with cationic polyamidoamine dendrimers (PAMAM-G3), namely G3@SeHANs, and compare the activities of G3@SeHANs with those of soluble PAMAM-G3 polymer. Both G3@SeHANs and PAMAM-G3 inhibit periodontitis-related proinflammation in vitro by scavenging cfDNA and alleviate inflammatory bone loss in a mouse model of ligature-induced periodontitis. G3@SeHANs also regulate the mononuclear phagocyte system in a periodontitis environment, promoting the M2 over the M1 macrophage phenotype. G3@SeHANs show greater therapeutic effects than PAMAM-G3 in reducing proinflammation and alveolar bone loss in vivo. Our findings demonstrate the importance of cfDNA in periodontitis and the potential for using hydroxyapatite-based nanoparticulate cfDNA scavengers to ameliorate periodontitis.
Suggested Citation
Hanyao Huang & Weiyi Pan & Yifan Wang & Hye Sung Kim & Dan Shao & Baoding Huang & Tzu-Chieh Ho & Yeh-Hsing Lao & Chai Hoon Quek & Jiayu Shi & Qianming Chen & Bing Shi & Shengmin Zhang & Lei Zhao & Kam, 2022.
"Nanoparticulate cell-free DNA scavenger for treating inflammatory bone loss in periodontitis,"
Nature Communications, Nature, vol. 13(1), pages 1-18, December.
Handle:
RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33492-6
DOI: 10.1038/s41467-022-33492-6
Download full text from publisher
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33492-6. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.