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Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage

Author

Listed:
  • Noriaki Arakawa

    (National Institute of Health Sciences)

  • Atsuhito Ushiki

    (Shinshu University School of Medicine)

  • Mitsuhiro Abe

    (Chiba University)

  • Shinichiro Matsuyama

    (National Institute of Health Sciences)

  • Yoshinobu Saito

    (Nippon Medical School)

  • Takeru Kashiwada

    (Nippon Medical School)

  • Yasushi Horimasu

    (Hiroshima University Hospital)

  • Akihiko Gemma

    (Nippon Medical School)

  • Koichiro Tatsumi

    (Chiba University)

  • Noboru Hattori

    (Hiroshima University)

  • Kenji Tsushima

    (International University of Health and Welfare)

  • Keiko Miyashita

    (National Institute of Health Sciences)

  • Kosuke Saito

    (National Institute of Health Sciences)

  • Ryosuke Nakamura

    (National Institute of Health Sciences)

  • Takeshi Toyoda

    (National Institute of Health Sciences)

  • Kumiko Ogawa

    (National Institute of Health Sciences)

  • Motonobu Sato

    (Astellas Pharma Inc)

  • Kazuhiko Takamatsu

    (Astellas Pharma Inc)

  • Kazuhiko Mori

    (Daiichi Sankyo RD Novare Co., Ltd)

  • Takayoshi Nishiya

    (Daiichi Sankyo RD Novare Co., Ltd)

  • Takashi Izumi

    (Kihara Memorial Foundation)

  • Yasuo Ohno

    (Kihara Memorial Foundation)

  • Yoshiro Saito

    (National Institute of Health Sciences)

  • Masayuki Hanaoka

    (Shinshu University School of Medicine)

Abstract

Among the various histopathological patterns of drug-induced interstitial lung disease (DILD), diffuse alveolar damage (DAD) is associated with poor prognosis. However, there is no reliable biomarker for its accurate diagnosis. Here, we show stratifin/14-3-3σ (SFN) as a biomarker candidate found in a proteomic analysis. The study includes two independent cohorts (including totally 26 patients with DAD) and controls (total 432 samples). SFN is specifically elevated in DILD patients with DAD, and is superior to the known biomarkers, KL-6 and SP-D, in discrimination of DILD patients with DAD from patients with other DILD patterns or other lung diseases. SFN is also increased in serum from patients with idiopathic DAD, and in lung tissues and bronchoalveolar lavage fluid of patients with DAD. In vitro analysis using cultured lung epithelial cells suggests that extracellular release of SFN occurs via p53-dependent apoptosis. We conclude that serum SFN is a promising biomarker for DAD diagnosis.

Suggested Citation

  • Noriaki Arakawa & Atsuhito Ushiki & Mitsuhiro Abe & Shinichiro Matsuyama & Yoshinobu Saito & Takeru Kashiwada & Yasushi Horimasu & Akihiko Gemma & Koichiro Tatsumi & Noboru Hattori & Kenji Tsushima & , 2022. "Stratifin as a novel diagnostic biomarker in serum for diffuse alveolar damage," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33160-9
    DOI: 10.1038/s41467-022-33160-9
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