Author
Listed:
- Shogo Ito
(Keio University School of Medicine
Kurume University School of Medicine)
- Hisayuki Hashimoto
(Keio University School of Medicine
Keio University School of Medicine)
- Hiroyuki Yamakawa
(Keio University School of Medicine
Keio University School of Medicine)
- Dai Kusumoto
(Keio University School of Medicine
Keio University School of Medicine)
- Yohei Akiba
(Keio University School of Medicine)
- Takahiro Nakamura
(Keio University School of Medicine)
- Mizuki Momoi
(Keio University School of Medicine)
- Jin Komuro
(Keio University School of Medicine)
- Toshiomi Katsuki
(Keio University School of Medicine)
- Mai Kimura
(Keio University School of Medicine)
- Yoshikazu Kishino
(Keio University School of Medicine)
- Shin Kashimura
(Keio University School of Medicine)
- Akira Kunitomi
(Keio University School of Medicine)
- Mark Lachmann
(Keio University School of Medicine)
- Masaya Shimojima
(Keio University School of Medicine)
- Gakuto Yozu
(Keio University School of Medicine)
- Chikaaki Motoda
(Keio University School of Medicine)
- Tomohisa Seki
(Keio University School of Medicine
The University of Tokyo Hospital)
- Tsunehisa Yamamoto
(Keio University School of Medicine)
- Yoshiki Shinya
(Keio University School of Medicine)
- Takahiro Hiraide
(Keio University School of Medicine)
- Masaharu Kataoka
(Keio University School of Medicine
University of Occupational and Environmental Health)
- Takashi Kawakami
(Keio University School of Medicine)
- Kunimichi Suzuki
(Keio University School of Medicine)
- Kei Ito
(National Defense Medical College)
- Hirotaka Yada
(National Defense Medical College
International University of Health and Welfare)
- Manabu Abe
(Brain Research Institute, Niigata University)
- Mizuko Osaka
(Tokyo Medical and Dental University)
- Hiromi Tsuru
(Tokyo Medical and Dental University)
- Masayuki Yoshida
(Tokyo Medical and Dental University)
- Kenji Sakimura
(Brain Research Institute, Niigata University)
- Yoshihiro Fukumoto
(Kurume University School of Medicine)
- Michisuke Yuzaki
(Keio University School of Medicine)
- Keiichi Fukuda
(Keio University School of Medicine)
- Shinsuke Yuasa
(Keio University School of Medicine)
Abstract
Failure of the right ventricle plays a critical role in any type of heart failure. However, the mechanism remains unclear, and there is no specific therapy. Here, we show that the right ventricle predominantly expresses alternative complement pathway-related genes, including Cfd and C3aR1. Complement 3 (C3)-knockout attenuates right ventricular dysfunction and fibrosis in a mouse model of right ventricular failure. C3a is produced from C3 by the C3 convertase complex, which includes the essential component complement factor D (Cfd). Cfd-knockout mice also show attenuation of right ventricular failure. Moreover, the plasma concentration of CFD correlates with the severity of right ventricular failure in patients with chronic right ventricular failure. A C3a receptor (C3aR) antagonist dramatically improves right ventricular dysfunction in mice. In summary, we demonstrate the crucial role of the C3-Cfd-C3aR axis in right ventricular failure and highlight potential therapeutic targets for right ventricular failure.
Suggested Citation
Shogo Ito & Hisayuki Hashimoto & Hiroyuki Yamakawa & Dai Kusumoto & Yohei Akiba & Takahiro Nakamura & Mizuki Momoi & Jin Komuro & Toshiomi Katsuki & Mai Kimura & Yoshikazu Kishino & Shin Kashimura & A, 2022.
"The complement C3-complement factor D-C3a receptor signalling axis regulates cardiac remodelling in right ventricular failure,"
Nature Communications, Nature, vol. 13(1), pages 1-12, December.
Handle:
RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33152-9
DOI: 10.1038/s41467-022-33152-9
Download full text from publisher
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33152-9. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.