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Immunogenicity decay and case incidence six months post Sinovac-CoronaVac vaccine in autoimmune rheumatic diseases patients

Author

Listed:
  • Clovis A. Silva

    (Universidade de Sao Paulo)

  • Ana C. Medeiros-Ribeiro

    (Universidade de Sao Paulo)

  • Leonard V. K. Kupa

    (Universidade de Sao Paulo)

  • Emily F. N. Yuki

    (Universidade de Sao Paulo)

  • Sandra G. Pasoto

    (Universidade de Sao Paulo)

  • Carla G. S. Saad

    (Universidade de Sao Paulo)

  • Solange R. G. Fusco

    (Universidade de Sao Paulo)

  • Rosa M. R. Pereira

    (Universidade de Sao Paulo)

  • Samuel K. Shinjo

    (Universidade de Sao Paulo)

  • Ari S. R. Halpern

    (Universidade de Sao Paulo)

  • Eduardo F. Borba

    (Universidade de Sao Paulo)

  • Fernando H. C. Souza

    (Universidade de Sao Paulo)

  • Lissiane K. N. Guedes

    (Universidade de Sao Paulo)

  • Renata Miossi

    (Universidade de Sao Paulo)

  • Karina R. Bonfiglioli

    (Universidade de Sao Paulo)

  • Diogo S. Domiciano

    (Universidade de Sao Paulo)

  • Andrea Y. Shimabuco

    (Universidade de Sao Paulo)

  • Danieli C. O. Andrade

    (Universidade de Sao Paulo)

  • Luciana P. C. Seguro

    (Universidade de Sao Paulo)

  • Ricardo Fuller

    (Universidade de Sao Paulo)

  • Percival D. Sampaio-Barros

    (Universidade de Sao Paulo)

  • Ana P. L. Assad

    (Universidade de Sao Paulo)

  • Julio C. B. Moraes

    (Universidade de Sao Paulo)

  • Claudia Goldenstein-Schainberg

    (Universidade de Sao Paulo)

  • Henrique A. M. Giardini

    (Universidade de Sao Paulo)

  • Henrique C. Silva

    (Universidade de Sao Paulo)

  • Victor A. O. Martins

    (Universidade de Sao Paulo)

  • Lorena E. B. Villamarin

    (Universidade de Sao Paulo)

  • Renata S. Novellino

    (Universidade de Sao Paulo)

  • Lucas P. Sales

    (Universidade de Sao Paulo)

  • Carlo S. R. Araújo

    (Universidade de Sao Paulo)

  • Matheus S. R. Silva

    (Universidade de Sao Paulo)

  • Dilson M. N. Filho

    (Universidade de Sao Paulo)

  • Marta H. Lopes

    (Universidade de Sao Paulo)

  • Alberto J. S. Duarte

    (Universidade de Sao Paulo)

  • Esper G. Kallas

    (Universidade de Sao Paulo)

  • Nadia E. Aikawa

    (Universidade de Sao Paulo)

  • Eloisa Bonfa

    (Universidade de Sao Paulo)

Abstract

The determination of durability and vaccine-associated protection is essential for booster doses strategies, however data on the stability of SARS-CoV-2 immunity are scarce. Here we assess anti-SARS-CoV-2 immunogenicity decay and incident cases six months after the 2nd dose of Sinovac-CoronaVac inactivated vaccine (D210) in 828 autoimmune rheumatic diseases patients compared with 207 age/sex-balanced control individuals. The primary outcome is the presence of anti-S1/S2 SARS-CoV-2 IgG at 6 months compared to 6 weeks after 2nd vaccine dose for decay evaluation. Secondary outcomes are presence of neutralizing antibodies, percent inhibition by neutralizing, geometric mean titers and cumulative incident cases at 6 months after 2nd dose. Anti-S1/S2 IgG positivity and titers reduce to 23.8% and 38% in patients (p

Suggested Citation

  • Clovis A. Silva & Ana C. Medeiros-Ribeiro & Leonard V. K. Kupa & Emily F. N. Yuki & Sandra G. Pasoto & Carla G. S. Saad & Solange R. G. Fusco & Rosa M. R. Pereira & Samuel K. Shinjo & Ari S. R. Halper, 2022. "Immunogenicity decay and case incidence six months post Sinovac-CoronaVac vaccine in autoimmune rheumatic diseases patients," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33042-0
    DOI: 10.1038/s41467-022-33042-0
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