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Mild dyslipidemia accelerates tumorigenesis through expansion of Ly6Chi monocytes and differentiation to pro-angiogenic myeloid cells

Author

Listed:
  • Thi Tran

    (Université Paris Cité, Inserm, PARCC)

  • Jean-Remi Lavillegrand

    (Université Paris Cité, Inserm, PARCC)

  • Cedric Lereverend

    (Université de Reims Champagne Ardenne, IRMAIC EA 7509)

  • Bruno Esposito

    (Université Paris Cité, Inserm, PARCC)

  • Lucille Cartier

    (Université de Reims Champagne Ardenne, IRMAIC EA 7509
    Institut Godinot)

  • Melanie Montabord

    (Université Paris Cité, Inserm, PARCC)

  • Jaouen Tran-Rajau

    (Université Paris Cité, Inserm, PARCC)

  • Marc Diedisheim

    (Service de diabétologie, Hôpital Cochin APHP. GlandOmics, Cheverny)

  • Nadège Gruel

    (INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, Institut Curie Research Centre, Institut Curie
    Institut Curie Research Centre, Institut Curie)

  • Khadija Ouguerram

    (Université de Nantes, INRAE, UMR 1280 PhAN)

  • Lea Paolini

    (Université Paris Cité, Inserm, PARCC)

  • Olivia Lenoir

    (Université Paris Cité, Inserm, PARCC)

  • Emmanuel Pinteaux

    (University of Manchester)

  • Eva Brabencova

    (Institut Godinot)

  • Corinne Tanchot

    (Université Paris Cité, Inserm, PARCC)

  • Pauline Urquia

    (Université Paris Cité, Inserm, PARCC)

  • Jacqueline Lehmann-Che

    (U976 HIPI
    Saint Louis Hospital, APHP)

  • Richard Le Naour

    (Université de Reims Champagne Ardenne, IRMAIC EA 7509)

  • Yacine Merrouche

    (Université de Reims Champagne Ardenne, IRMAIC EA 7509
    Institut Godinot)

  • Christian Stockmann

    (Université Paris Cité, Inserm, PARCC
    University of Zurich, Institute of Anatomy
    Comprehensive Cancer Center Zurich)

  • Ziad Mallat

    (Université Paris Cité, Inserm, PARCC
    University of Cambridge)

  • Alain Tedgui

    (Université Paris Cité, Inserm, PARCC)

  • Hafid Ait-Oufella

    (Université Paris Cité, Inserm, PARCC)

  • Eric Tartour

    (Université Paris Cité, Inserm, PARCC
    Equipe Labellisée Ligue Contre le Cancer
    AP-HP Hôpital Européen Georges Pompidou. Service d’immunologie)

  • Stephane Potteaux

    (Université Paris Cité, Inserm, PARCC
    U976 HIPI)

Abstract

Cancer and cardiovascular disease (CVD) share common risk factors such as dyslipidemia, obesity and inflammation. However, the role of pro-atherogenic environment and its associated low-grade inflammation in tumor progression remains underexplored. Here we show that feeding C57BL/6J mice with a non-obesogenic high fat high cholesterol diet (HFHCD) for two weeks to induce mild dyslipidemia, increases the pool of circulating Ly6Chi monocytes available for initial melanoma development, in an IL-1β-dependent manner. Descendants of circulating myeloid cells, which accumulate in the tumor microenvironment of mice under HFHCD, heighten pro-angiogenic and immunosuppressive activities locally. Limiting myeloid cell accumulation or targeting VEGF-A production by myeloid cells decrease HFHCD-induced tumor growth acceleration. Reverting the HFHCD to a chow diet at the time of tumor implantation protects against tumor growth. Together, these data shed light on cross-disease communication between cardiovascular pathologies and cancer.

Suggested Citation

  • Thi Tran & Jean-Remi Lavillegrand & Cedric Lereverend & Bruno Esposito & Lucille Cartier & Melanie Montabord & Jaouen Tran-Rajau & Marc Diedisheim & Nadège Gruel & Khadija Ouguerram & Lea Paolini & Ol, 2022. "Mild dyslipidemia accelerates tumorigenesis through expansion of Ly6Chi monocytes and differentiation to pro-angiogenic myeloid cells," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33034-0
    DOI: 10.1038/s41467-022-33034-0
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    References listed on IDEAS

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    1. Ralph Klose & Ewelina Krzywinska & Magali Castells & Dagmar Gotthardt & Eva Maria Putz & Chahrazade Kantari-Mimoun & Naima Chikdene & Anna-Katharina Meinecke & Katrin Schrödter & Iris Helfrich & Joach, 2016. "Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia," Nature Communications, Nature, vol. 7(1), pages 1-14, November.
    2. Partha Dutta & Gabriel Courties & Ying Wei & Florian Leuschner & Rostic Gorbatov & Clinton S. Robbins & Yoshiko Iwamoto & Brian Thompson & Alicia L. Carlson & Timo Heidt & Maulik D. Majmudar & Felix L, 2012. "Myocardial infarction accelerates atherosclerosis," Nature, Nature, vol. 487(7407), pages 325-329, July.
    3. Chao Liu & Tianxu Han & David L. Stachura & Huawei Wang & Boris L. Vaisman & Jungsu Kim & Richard L. Klemke & Alan T. Remaley & Tariq M. Rana & David Traver & Yury I. Miller, 2018. "Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
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