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McaA and McaB control the dynamic positioning of a bacterial magnetic organelle

Author

Listed:
  • Juan Wan

    (University of California)

  • Caroline L. Monteil

    (Institute of Biosciences and Biotechnologies of Aix-Marseille)

  • Azuma Taoka

    (Kanazawa University)

  • Gabriel Ernie

    (University of California)

  • Kieop Park

    (University of California
    Duke University)

  • Matthieu Amor

    (University of California
    Institute of Biosciences and Biotechnologies of Aix-Marseille)

  • Elias Taylor-Cornejo

    (University of California
    Randolph-Macon College)

  • Christopher T. Lefevre

    (Institute of Biosciences and Biotechnologies of Aix-Marseille)

  • Arash Komeili

    (University of California)

Abstract

Magnetotactic bacteria are a diverse group of microorganisms that use intracellular chains of ferrimagnetic nanocrystals, produced within magnetosome organelles, to align and navigate along the geomagnetic field. Several conserved genes for magnetosome formation have been described, but the mechanisms leading to distinct species-specific magnetosome chain configurations remain unclear. Here, we show that the fragmented nature of magnetosome chains in Magnetospirillum magneticum AMB-1 is controlled by genes mcaA and mcaB. McaA recognizes the positive curvature of the inner cell membrane, while McaB localizes to magnetosomes. Along with the MamK actin-like cytoskeleton, McaA and McaB create space for addition of new magnetosomes in between pre-existing magnetosomes. Phylogenetic analyses suggest that McaA and McaB homologs are widespread among magnetotactic bacteria and may represent an ancient strategy for magnetosome positioning.

Suggested Citation

  • Juan Wan & Caroline L. Monteil & Azuma Taoka & Gabriel Ernie & Kieop Park & Matthieu Amor & Elias Taylor-Cornejo & Christopher T. Lefevre & Arash Komeili, 2022. "McaA and McaB control the dynamic positioning of a bacterial magnetic organelle," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32914-9
    DOI: 10.1038/s41467-022-32914-9
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    References listed on IDEAS

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    1. Carly R. Grant & Matthieu Amor & Hector A. Trujillo & Sunaya Krishnapura & Anthony T. Iavarone & Arash Komeili, 2022. "Distinct gene clusters drive formation of ferrosome organelles in bacteria," Nature, Nature, vol. 606(7912), pages 160-164, June.
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