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Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen

Author

Listed:
  • Ayaka Washizaki

    (Kyoto University)

  • Asako Murayama

    (National Institute of Infectious Diseases)

  • Megumi Murata

    (Kyoto University)

  • Tomoko Kiyohara

    (National Institute of Infectious Diseases)

  • Keigo Yato

    (National Institute of Infectious Diseases)

  • Norie Yamada

    (National Institute of Infectious Diseases)

  • Hussein Hassan Aly

    (National Institute of Infectious Diseases)

  • Tomohisa Tanaka

    (University of Yamanashi)

  • Kohji Moriishi

    (University of Yamanashi
    Hokkaido University)

  • Hironori Nishitsuji

    (Fujita Health University School of Medicine)

  • Kunitada Shimotohno

    (National Center for Global Health and Medicine)

  • Yasumasa Goh

    (Research Laboratory, Beacle, Inc.)

  • Ken J. Ishii

    (The University of Tokyo)

  • Hiroshi Yotsuyanagi

    (The University of Tokyo)

  • Masamichi Muramatsu

    (National Institute of Infectious Diseases)

  • Koji Ishii

    (National Institute of Infectious Diseases)

  • Yoshimasa Takahashi

    (National Institute of Infectious Diseases)

  • Ryosuke Suzuki

    (National Institute of Infectious Diseases)

  • Hirofumi Akari

    (Kyoto University)

  • Takanobu Kato

    (National Institute of Infectious Diseases)

Abstract

Although the current hepatitis B (HB) vaccine comprising small-HBs antigen (Ag) is potent and safe, attenuated prophylaxis against hepatitis B virus (HBV) with vaccine-escape mutations (VEMs) has been reported. We investigate an HB vaccine consisting of large-HBsAg that overcomes the shortcomings of the current HB vaccine. Yeast-derived large-HBsAg is immunized into rhesus macaques, and the neutralizing activities of the induced antibodies are compared with those of the current HB vaccine. Although the antibodies induced by the current HB vaccine cannot prevent HBV infection with VEMs, the large-HBsAg vaccine-induced antibodies neutralize those infections. The HBV genotypes that exhibited attenuated neutralization via these vaccines are different. Here, we show that the HB vaccine consisting of large-HBsAg is useful to compensate for the shortcomings of the current HB vaccine. The combined use of these HB vaccines may induce antibodies that can neutralize HBV strains with VEMs or multiple HBV genotypes.

Suggested Citation

  • Ayaka Washizaki & Asako Murayama & Megumi Murata & Tomoko Kiyohara & Keigo Yato & Norie Yamada & Hussein Hassan Aly & Tomohisa Tanaka & Kohji Moriishi & Hironori Nishitsuji & Kunitada Shimotohno & Yas, 2022. "Neutralization of hepatitis B virus with vaccine-escape mutations by hepatitis B vaccine with large-HBs antigen," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32910-z
    DOI: 10.1038/s41467-022-32910-z
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