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A Cryptochrome adopts distinct moon- and sunlight states and functions as sun- versus moonlight interpreter in monthly oscillator entrainment

Author

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  • Birgit Poehn

    (Max Perutz Labs, University of Vienna, Vienna BioCenter
    Research Platform “Rhythms of Life”, University of Vienna, Vienna BioCenter)

  • Shruthi Krishnan

    (Johannes Gutenberg-University
    Institute of Molecular Biology (IMB))

  • Martin Zurl

    (Max Perutz Labs, University of Vienna, Vienna BioCenter
    Research Platform “Rhythms of Life”, University of Vienna, Vienna BioCenter)

  • Aida Coric

    (Max Perutz Labs, University of Vienna, Vienna BioCenter
    Research Platform “Rhythms of Life”, University of Vienna, Vienna BioCenter)

  • Dunja Rokvic

    (Max Perutz Labs, University of Vienna, Vienna BioCenter
    Research Platform “Rhythms of Life”, University of Vienna, Vienna BioCenter)

  • N. Sören Häfker

    (Max Perutz Labs, University of Vienna, Vienna BioCenter
    Research Platform “Rhythms of Life”, University of Vienna, Vienna BioCenter)

  • Elmar Jaenicke

    (Johannes Gutenberg-University)

  • Enrique Arboleda

    (Max Perutz Labs, University of Vienna, Vienna BioCenter
    Research Platform “Rhythms of Life”, University of Vienna, Vienna BioCenter
    Institut de Génomique Fonctionnelle de Lyon (IGFL), École Normale Supérieure de Lyon)

  • Lukas Orel

    (Max Perutz Labs, University of Vienna, Vienna BioCenter
    Research Platform “Rhythms of Life”, University of Vienna, Vienna BioCenter)

  • Florian Raible

    (Max Perutz Labs, University of Vienna, Vienna BioCenter
    Research Platform “Rhythms of Life”, University of Vienna, Vienna BioCenter)

  • Eva Wolf

    (Johannes Gutenberg-University
    Institute of Molecular Biology (IMB))

  • Kristin Tessmar-Raible

    (Max Perutz Labs, University of Vienna, Vienna BioCenter
    Research Platform “Rhythms of Life”, University of Vienna, Vienna BioCenter
    Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research
    Carl-von-Ossietzky University)

Abstract

The moon’s monthly cycle synchronizes reproduction in countless marine organisms. The mass-spawning bristle worm Platynereis dumerilii uses an endogenous monthly oscillator set by full moon to phase reproduction to specific days. But how do organisms recognize specific moon phases? We uncover that the light receptor L-Cryptochrome (L-Cry) discriminates between different moonlight durations, as well as between sun- and moonlight. A biochemical characterization of purified L-Cry protein, exposed to naturalistic sun- or moonlight, reveals the formation of distinct sun- and moonlight states characterized by different photoreduction- and recovery kinetics of L-Cry’s co-factor Flavin Adenine Dinucleotide. In Platynereis, L-Cry’s sun- versus moonlight states correlate with distinct subcellular localizations, indicating different signaling. In contrast, r-Opsin1, the most abundant ocular opsin, is not required for monthly oscillator entrainment. Our work reveals a photo-ecological concept for natural light interpretation involving a “valence interpreter” that provides entraining photoreceptor(s) with light source and moon phase information.

Suggested Citation

  • Birgit Poehn & Shruthi Krishnan & Martin Zurl & Aida Coric & Dunja Rokvic & N. Sören Häfker & Elmar Jaenicke & Enrique Arboleda & Lukas Orel & Florian Raible & Eva Wolf & Kristin Tessmar-Raible, 2022. "A Cryptochrome adopts distinct moon- and sunlight states and functions as sun- versus moonlight interpreter in monthly oscillator entrainment," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32562-z
    DOI: 10.1038/s41467-022-32562-z
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    References listed on IDEAS

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    1. Tobias S. Kaiser & Birgit Poehn & David Szkiba & Marco Preussner & Fritz J. Sedlazeck & Alexander Zrim & Tobias Neumann & Lam-Tung Nguyen & Andrea J. Betancourt & Thomas Hummel & Heiko Vogel & Silke D, 2016. "The genomic basis of circadian and circalunar timing adaptations in a midge," Nature, Nature, vol. 540(7631), pages 69-73, December.
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    Cited by:

    1. Hong Ha Vu & Heide Behrmann & Maja Hanić & Gayathri Jeyasankar & Shruthi Krishnan & Dennis Dannecker & Constantin Hammer & Monika Gunkel & Ilia A. Solov’yov & Eva Wolf & Elmar Behrmann, 2023. "A marine cryptochrome with an inverse photo-oligomerization mechanism," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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