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Conserved subcortical processing in visuo-vestibular gaze control

Author

Listed:
  • Tobias Wibble

    (Karolinska Institutet
    Karolinska Institutet)

  • Tony Pansell

    (Karolinska Institutet)

  • Sten Grillner

    (Karolinska Institutet)

  • Juan Pérez-Fernández

    (Karolinska Institutet
    CINBIO, Universidade de Vigo, Neurocircuits Group, Campus universitario Lagoas)

Abstract

Gaze stabilization compensates for movements of the head or external environment to minimize image blurring. Multisensory information stabilizes the scene on the retina via the vestibulo-ocular (VOR) and optokinetic (OKR) reflexes. While the organization of neuronal circuits underlying VOR is well-described across vertebrates, less is known about the contribution and evolution of the OKR and the basic structures allowing visuo-vestibular integration. To analyze these neuronal pathways underlying visuo-vestibular integration, we developed a setup using a lamprey eye-brain-labyrinth preparation, which allowed coordinating electrophysiological recordings, vestibular stimulation with a moving platform, and visual stimulation via screens. Lampreys exhibit robust visuo-vestibular integration, with optokinetic information processed in the pretectum that can be downregulated from tectum. Visual and vestibular inputs are integrated at several subcortical levels. Additionally, saccades are present in the form of nystagmus. Thus, all basic components of the visuo-vestibular control of gaze were present already at the dawn of vertebrate evolution.

Suggested Citation

  • Tobias Wibble & Tony Pansell & Sten Grillner & Juan Pérez-Fernández, 2022. "Conserved subcortical processing in visuo-vestibular gaze control," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32379-w
    DOI: 10.1038/s41467-022-32379-w
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    References listed on IDEAS

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    1. Shinnosuke Higuchi & Fumiaki Sugahara & Juan Pascual-Anaya & Wataru Takagi & Yasuhiro Oisi & Shigeru Kuratani, 2019. "Inner ear development in cyclostomes and evolution of the vertebrate semicircular canals," Nature, Nature, vol. 565(7739), pages 347-350, January.
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