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A conflict between spatial selection and evidence accumulation in area LIP

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  • Joshua A. Seideman

    (Department of Neurobiology and Anatomy, Wake Forest School of Medicine)

  • Terrence R. Stanford

    (Department of Neurobiology and Anatomy, Wake Forest School of Medicine)

  • Emilio Salinas

    (Department of Neurobiology and Anatomy, Wake Forest School of Medicine)

Abstract

The lateral intraparietal area (LIP) contains spatially selective neurons that help guide eye movements and, according to numerous studies, do so by accumulating sensory evidence in favor of one choice (e.g., look left) or another (look right). To examine this functional link, we trained two monkeys on an urgent motion discrimination task, a task with which the evolution of both the recorded neuronal activity and the subject’s choice can be tracked millisecond by millisecond. We found that while choice accuracy increased steeply with increasing sensory evidence, at the same time, the LIP selection signal became progressively weaker, as if it hindered performance. This effect was consistent with the transient deployment of spatial attention to disparate locations away from the relevant sensory cue. The results demonstrate that spatial selection in LIP is dissociable from, and may even conflict with, evidence accumulation during informed saccadic choices.

Suggested Citation

  • Joshua A. Seideman & Terrence R. Stanford & Emilio Salinas, 2022. "A conflict between spatial selection and evidence accumulation in area LIP," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32209-z
    DOI: 10.1038/s41467-022-32209-z
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    References listed on IDEAS

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    1. Leor N. Katz & Jacob L. Yates & Jonathan W. Pillow & Alexander C. Huk, 2016. "Dissociated functional significance of decision-related activity in the primate dorsal stream," Nature, Nature, vol. 535(7611), pages 285-288, July.
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