IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-32198-z.html
   My bibliography  Save this article

Molecular characterization of colorectal cancer related peritoneal metastatic disease

Author

Listed:
  • Kristiaan J. Lenos

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Sander Bach

    (Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam)

  • Leandro Ferreira Moreno

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Sanne Hoorn

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Nina R. Sluiter

    (Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam)

  • Sanne Bootsma

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Felipe A. Vieira Braga

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Lisanne E. Nijman

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Tom Bosch

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Daniel M. Miedema

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Erik Dijk

    (Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam)

  • Bauke Ylstra

    (Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam)

  • Ruth Kulicke

    (Celsius Therapeutics)

  • Fred P. Davis

    (Celsius Therapeutics)

  • Nicolas Stransky

    (Celsius Therapeutics)

  • Gromoslaw A. Smolen

    (Celsius Therapeutics)

  • Robert R. J. Coebergh van den Braak

    (Erasmus MC University Medical Center)

  • Jan N. M. IJzermans

    (Erasmus MC University Medical Center)

  • John W. M. Martens

    (Erasmus MC University Medical Center, Rotterdam, the Netherlands & Cancer Genomics Center)

  • Sally Hallam

    (University of Birmingham)

  • Andrew D. Beggs

    (University of Birmingham)

  • Geert J. P. L. Kops

    (Oncode Institute
    Hubrecht institute-KNAW and University Medical Center Utrecht)

  • Nico Lansu

    (Oncode Institute
    Hubrecht institute-KNAW and University Medical Center Utrecht)

  • Vivian P. Bastiaenen

    (Amsterdam UMC location University of Amsterdam, Department of Surgery, Cancer Center Amsterdam)

  • Charlotte E. L. Klaver

    (Amsterdam UMC location University of Amsterdam, Department of Surgery, Cancer Center Amsterdam)

  • Maria C. Lecca

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Khalid El Makrini

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Clara C. Elbers

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Mark P. G. Dings

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Carel J. M. Noesel

    (Amsterdam UMC location University of Amsterdam, Department of Pathology, Cancer Center Amsterdam)

  • Onno Kranenburg

    (University Medical Center Utrecht)

  • Jan Paul Medema

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Jan Koster

    (Amsterdam UMC location University of Amsterdam, Department of Oncogenomics, Meibergdreef 9)

  • Lianne Koens

    (Amsterdam UMC location University of Amsterdam, Department of Pathology, Cancer Center Amsterdam)

  • Cornelis J. A. Punt

    (Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University)

  • Pieter J. Tanis

    (Amsterdam UMC location University of Amsterdam, Department of Surgery, Cancer Center Amsterdam)

  • Ignace H. Hingh

    (Maastricht University)

  • Maarten F. Bijlsma

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Jurriaan B. Tuynman

    (Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam)

  • Louis Vermeulen

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute
    Amsterdam UMC location University of Amsterdam, Department of Medical Oncology, Cancer Center Amsterdam)

Abstract

A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the molecular characteristics of CRC-PM is required. Here we present a comprehensive molecular characterization of a cohort of 52 patients. This reveals that CRC-PM represent a distinct CRC molecular subtype, CMS4, but can be further divided in three separate categories, each presenting with unique features. We uncover that the CMS4-associated structural protein Moesin plays a key role in peritoneal dissemination. Finally, we define specific evolutionary features of CRC-PM which indicate that polyclonal metastatic seeding underlies these lesions. Together our results suggest that CRC-PM should be perceived as a distinct disease entity.

Suggested Citation

  • Kristiaan J. Lenos & Sander Bach & Leandro Ferreira Moreno & Sanne Hoorn & Nina R. Sluiter & Sanne Bootsma & Felipe A. Vieira Braga & Lisanne E. Nijman & Tom Bosch & Daniel M. Miedema & Erik Dijk & Ba, 2022. "Molecular characterization of colorectal cancer related peritoneal metastatic disease," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32198-z
    DOI: 10.1038/s41467-022-32198-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-32198-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-32198-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Erik Dijk & Tom Bosch & Kristiaan J. Lenos & Khalid El Makrini & Lisanne E. Nijman & Hendrik F. B. Essen & Nico Lansu & Michiel Boekhout & Joris H. Hageman & Rebecca C. Fitzgerald & Cornelis J. A. Pun, 2021. "Chromosomal copy number heterogeneity predicts survival rates across cancers," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Carolin M. Sauer & James A. Hall & Dominique-Laurent Couturier & Thomas Bradley & Anna M. Piskorz & Jacob Griffiths & Ashley Sawle & Matthew D. Eldridge & Philip Smith & Karen Hosking & Marika A. V. R, 2023. "Molecular landscape and functional characterization of centrosome amplification in ovarian cancer," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Leanne M. Brown & Ryan A. Hagenson & Tilen Koklič & Iztok Urbančič & Lu Qiao & Janez Strancar & Jason M. Sheltzer, 2024. "An elevated rate of whole-genome duplications in cancers from Black patients," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Philip Smith & Thomas Bradley & Lena Morrill Gavarró & Teodora Goranova & Darren P. Ennis & Hasan B. Mirza & Dilrini Silva & Anna M. Piskorz & Carolin M. Sauer & Sarwah Al-Khalidi & Ionut-Gabriel Funi, 2023. "The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32198-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.