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Molecular characterization of colorectal cancer related peritoneal metastatic disease

Author

Listed:
  • Kristiaan J. Lenos

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Sander Bach

    (Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam)

  • Leandro Ferreira Moreno

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Sanne Hoorn

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Nina R. Sluiter

    (Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam)

  • Sanne Bootsma

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Felipe A. Vieira Braga

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Lisanne E. Nijman

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Tom Bosch

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Daniel M. Miedema

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Erik Dijk

    (Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam)

  • Bauke Ylstra

    (Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Pathology, Cancer Center Amsterdam)

  • Ruth Kulicke

    (Celsius Therapeutics)

  • Fred P. Davis

    (Celsius Therapeutics)

  • Nicolas Stransky

    (Celsius Therapeutics)

  • Gromoslaw A. Smolen

    (Celsius Therapeutics)

  • Robert R. J. Coebergh van den Braak

    (Erasmus MC University Medical Center)

  • Jan N. M. IJzermans

    (Erasmus MC University Medical Center)

  • John W. M. Martens

    (Erasmus MC University Medical Center, Rotterdam, the Netherlands & Cancer Genomics Center)

  • Sally Hallam

    (University of Birmingham)

  • Andrew D. Beggs

    (University of Birmingham)

  • Geert J. P. L. Kops

    (Oncode Institute
    Hubrecht institute-KNAW and University Medical Center Utrecht)

  • Nico Lansu

    (Oncode Institute
    Hubrecht institute-KNAW and University Medical Center Utrecht)

  • Vivian P. Bastiaenen

    (Amsterdam UMC location University of Amsterdam, Department of Surgery, Cancer Center Amsterdam)

  • Charlotte E. L. Klaver

    (Amsterdam UMC location University of Amsterdam, Department of Surgery, Cancer Center Amsterdam)

  • Maria C. Lecca

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Khalid El Makrini

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Clara C. Elbers

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Mark P. G. Dings

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Carel J. M. Noesel

    (Amsterdam UMC location University of Amsterdam, Department of Pathology, Cancer Center Amsterdam)

  • Onno Kranenburg

    (University Medical Center Utrecht)

  • Jan Paul Medema

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Jan Koster

    (Amsterdam UMC location University of Amsterdam, Department of Oncogenomics, Meibergdreef 9)

  • Lianne Koens

    (Amsterdam UMC location University of Amsterdam, Department of Pathology, Cancer Center Amsterdam)

  • Cornelis J. A. Punt

    (Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht University)

  • Pieter J. Tanis

    (Amsterdam UMC location University of Amsterdam, Department of Surgery, Cancer Center Amsterdam)

  • Ignace H. Hingh

    (Maastricht University)

  • Maarten F. Bijlsma

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute)

  • Jurriaan B. Tuynman

    (Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Surgery, Cancer Center Amsterdam)

  • Louis Vermeulen

    (Amsterdam UMC location University of Amsterdam, Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Cancer Center Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism
    Oncode Institute
    Amsterdam UMC location University of Amsterdam, Department of Medical Oncology, Cancer Center Amsterdam)

Abstract

A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the molecular characteristics of CRC-PM is required. Here we present a comprehensive molecular characterization of a cohort of 52 patients. This reveals that CRC-PM represent a distinct CRC molecular subtype, CMS4, but can be further divided in three separate categories, each presenting with unique features. We uncover that the CMS4-associated structural protein Moesin plays a key role in peritoneal dissemination. Finally, we define specific evolutionary features of CRC-PM which indicate that polyclonal metastatic seeding underlies these lesions. Together our results suggest that CRC-PM should be perceived as a distinct disease entity.

Suggested Citation

  • Kristiaan J. Lenos & Sander Bach & Leandro Ferreira Moreno & Sanne Hoorn & Nina R. Sluiter & Sanne Bootsma & Felipe A. Vieira Braga & Lisanne E. Nijman & Tom Bosch & Daniel M. Miedema & Erik Dijk & Ba, 2022. "Molecular characterization of colorectal cancer related peritoneal metastatic disease," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32198-z
    DOI: 10.1038/s41467-022-32198-z
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    References listed on IDEAS

    as
    1. Erik Dijk & Tom Bosch & Kristiaan J. Lenos & Khalid El Makrini & Lisanne E. Nijman & Hendrik F. B. Essen & Nico Lansu & Michiel Boekhout & Joris H. Hageman & Rebecca C. Fitzgerald & Cornelis J. A. Pun, 2021. "Chromosomal copy number heterogeneity predicts survival rates across cancers," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

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