IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-31908-x.html
   My bibliography  Save this article

Development of a novel core genome MLST scheme for tracing multidrug resistant Staphylococcus capitis

Author

Listed:
  • Zhengan Wang

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine)

  • Chao Gu

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    The First Hospital of Jiaxing (the Affiliated Hospital of Jiaxing University))

  • Lu Sun

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine)

  • Feng Zhao

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province)

  • Ying Fu

    (Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province)

  • Lingfang Di

    (Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Tongxiang First people’s hospital)

  • Junxiong Zhang

    (Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Linping Traditional Chinese Medicine Hospital)

  • Hemu Zhuang

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine)

  • Shengnan Jiang

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine)

  • Haiping Wang

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine)

  • Feiteng Zhu

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine)

  • Yiyi Chen

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine)

  • Mengzhen Chen

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine)

  • Xia Ling

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Blood center of Zhejiang province)

  • Yan Chen

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine)

  • Yunsong Yu

    (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
    Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine)

Abstract

Staphylococcus capitis, which causes bloodstream infections in neonatal intensive care units, is a common cause of healthcare-associated infections. Thus, a standardized high-resolution typing method to document the transmission and dissemination of multidrug-resistant S. capitis isolates is required. We aimed to establish a core genome multilocus sequence typing (cgMLST) scheme to surveil S. capitis. The cgMLST scheme was defined based on primary and validation genome sets and tested with outbreaks of linezolid-resistant isolates and a validation set. Phylogenetic analysis was performed to investigate the population structure and compare it with the result of cgMLST analysis. The S. capitis population consists of 1 dominant, NRCS-A, and 4 less common clones. In this work, a multidrug-resistant clone (L clone) with linezolid resistance is identified. With the features of type III SCCmec and multiple copies of mutations of G2576T and C2104T in the 23S rRNA, the L clone has been spreading silently across China.

Suggested Citation

  • Zhengan Wang & Chao Gu & Lu Sun & Feng Zhao & Ying Fu & Lingfang Di & Junxiong Zhang & Hemu Zhuang & Shengnan Jiang & Haiping Wang & Feiteng Zhu & Yiyi Chen & Mengzhen Chen & Xia Ling & Yan Chen & Yun, 2022. "Development of a novel core genome MLST scheme for tracing multidrug resistant Staphylococcus capitis," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31908-x
    DOI: 10.1038/s41467-022-31908-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-31908-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-31908-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31908-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.