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Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection

Author

Listed:
  • T. Ferry

    (Hôpital de la Croix-rousse, Hospices Civils de Lyon
    Université Claude Bernard Lyon 1
    Hospices Civils de Lyon
    CIRI, Inserm U1111, CNRS UMR5308, ENS de Lyon)

  • C. Kolenda

    (Université Claude Bernard Lyon 1
    Hospices Civils de Lyon
    CIRI, Inserm U1111, CNRS UMR5308, ENS de Lyon
    Hôpital de la Croix-rousse, Hospices Civils de Lyon)

  • F. Laurent

    (Université Claude Bernard Lyon 1
    Hospices Civils de Lyon
    CIRI, Inserm U1111, CNRS UMR5308, ENS de Lyon
    Hôpital de la Croix-rousse, Hospices Civils de Lyon)

  • G. Leboucher

    (Hôpital de la Croix-rousse, Hospices Civils de Lyon)

  • M. Merabischvilli

    (Queen Astrid Military Hospital)

  • S. Djebara

    (Queen Astrid Military Hospital)

  • C.-A. Gustave

    (Université Claude Bernard Lyon 1
    CIRI, Inserm U1111, CNRS UMR5308, ENS de Lyon
    Hôpital de la Croix-rousse, Hospices Civils de Lyon)

  • T. Perpoint

    (Hôpital de la Croix-rousse, Hospices Civils de Lyon)

  • C. Barrey

    (Hôpital Pierre Wertheimer, Hospices Civils de Lyon)

  • J.-P. Pirnay

    (Queen Astrid Military Hospital)

  • G. Resch

    (Lausanne University Hospital)

Abstract

Bone and joint infections (BJI) are one of the most difficult-to-treat bacterial infection, especially in the era of antimicrobial resistance. Lytic bacteriophages (phages for short) are natural viruses that can selectively target and kill bacteria. They are considered to have a high therapeutic potential for the treatment of severe bacterial infections and especially BJI, as they also target biofilms. Here we report on the management of a patient with a pandrug-resistant Pseudomonas aeruginosa spinal abscess who was treated with surgery and a personalized combination of phage therapy that was added to antibiotics. As the infecting P. aeruginosa strain was resistant to the phages developed by private companies that were contacted, we set up a unique European academic collaboration to find, produce and administer a personalized phage cocktail to the patient in due time. After two surgeries, despite bacterial persistence with expression of small colony variants, the patient healed with local and intravenous injections of purified phages as adjuvant therapy.

Suggested Citation

  • T. Ferry & C. Kolenda & F. Laurent & G. Leboucher & M. Merabischvilli & S. Djebara & C.-A. Gustave & T. Perpoint & C. Barrey & J.-P. Pirnay & G. Resch, 2022. "Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection," Nature Communications, Nature, vol. 13(1), pages 1-6, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31837-9
    DOI: 10.1038/s41467-022-31837-9
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    Cited by:

    1. Thilo Köhler & Alexandre Luscher & Léna Falconnet & Grégory Resch & Robert McBride & Quynh-Anh Mai & Juliette L. Simonin & Marc Chanson & Bohumil Maco & Raphaël Galiotto & Arnaud Riat & Natacha Civic , 2023. "Personalized aerosolised bacteriophage treatment of a chronic lung infection due to multidrug-resistant Pseudomonas aeruginosa," Nature Communications, Nature, vol. 14(1), pages 1-10, December.

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